Data used in this analysis

Specifically, in this experiment set, known experiment labels are:

General description

This report contains all the functional information that was requested by the options when functional_Hunter.R was executed. The functional categories can be:

+ Biological Process + Molecular Function + Cellular Component

All the functional categories are computed with ClusterProfiler and GO categories are computed also with TopGo.

Some sections will not show if there are not sinficative results. Each category is analysed using Over representation analysis (ORA) and Gene Set Analysis (GSEA). The ORA method takes a group of significative DEGs (only DEGs, upregulated DEGs or downregulated DEGs) and performs a hypergeometric test for each term of the selected functional category. In the case of the GSEA method, all the genes are sorted by their fold-change and the algorithm scan which genes with similar fold-change shares a term of the selected functional category.

Statistics about input results obtained from DEGenes Expression Hunter are:

Gene_tag Genes
NOT_DEG 16704
POSSIBLE_DEG 37
PREVALENT_DEG 63

Top genes

Table of signifcant genes. Variables taken into account are being shown into table (except gene symbols/ID). Top of positive (20 items) and negative (18 items) are being shown in two different tables

Top positive

rownames input_IDs logFC_DESeq2 logFC_edgeR mean_logFCs SYMBOL
ENSG00000107562 ENSG00000107562 2.50073013395375 2.50589129791027 2.50331071593201 CXCL12
ENSG00000075223 ENSG00000075223 2.56308377116416 2.53404815740822 2.54856596428619 SEMA3C
ENSG00000135373 ENSG00000135373 2.65118568841675 2.62199619589012 2.63659094215344 EHF
ENSG00000164120 ENSG00000164120 2.77190352564574 2.72574791320353 2.74882571942464 HPGD
ENSG00000152207 ENSG00000152207 2.78190686861342 2.72410161009241 2.75300423935292 CYSLTR2
ENSG00000166535 ENSG00000166535 3.28602748954438 3.23761339002102 3.2618204397827 A2ML1
ENSG00000198848 ENSG00000198848 4.89654791300351 5.6871371658295 5.2918425394165 CES1
ENSG00000227425 ENSG00000227425 4.90797507515821 5.69191001777592 5.29994254646707 NA
ENSG00000073754 ENSG00000073754 5.05869839771353 5.0382064256174 5.04845241166547 CD5L
ENSG00000163534 ENSG00000163534 5.17275132262055 5.16057170679365 5.1666615147071 FCRL1
ENSG00000132704 ENSG00000132704 5.20333662540855 5.02668368561451 5.11501015551153 FCRL2
ENSG00000248837 ENSG00000248837 5.45459712833339 5.2340626269356 5.3443298776345 LOC105374524
ENSG00000223756 ENSG00000223756 5.8137796438807 6.58085065215153 6.19731514801611 NA
ENSG00000228065 ENSG00000228065 5.9013462920888 5.67629893150035 5.78882261179458 NA
ENSG00000249948 ENSG00000249948 6.27363776230444 7.04452761048229 6.65908268639336 GBA3
ENSG00000105492 ENSG00000105492 2.94168223373985 2.88806561540889 2.91487392457437 SIGLEC6
ENSG00000173218 ENSG00000173218 3.11191964307186 2.959942454356 3.03593104871393 VANGL1
ENSG00000250107 ENSG00000250107 3.180800473785 3.01850158237708 3.09965102808104 CACNA1G-AS1
ENSG00000128274 ENSG00000128274 3.29622259074658 3.1243277128575 3.21027515180204 A4GALT
ENSG00000204460 ENSG00000204460 3.66131177483749 3.40876502389018 3.53503839936384 LINC01854

Top negative

rownames input_IDs logFC_DESeq2 logFC_edgeR mean_logFCs SYMBOL
ENSG00000107562 ENSG00000107562 2.50073013395375 2.50589129791027 2.50331071593201 CXCL12
ENSG00000075223 ENSG00000075223 2.56308377116416 2.53404815740822 2.54856596428619 SEMA3C
ENSG00000135373 ENSG00000135373 2.65118568841675 2.62199619589012 2.63659094215344 EHF
ENSG00000164120 ENSG00000164120 2.77190352564574 2.72574791320353 2.74882571942464 HPGD
ENSG00000152207 ENSG00000152207 2.78190686861342 2.72410161009241 2.75300423935292 CYSLTR2
ENSG00000166535 ENSG00000166535 3.28602748954438 3.23761339002102 3.2618204397827 A2ML1
ENSG00000198848 ENSG00000198848 4.89654791300351 5.6871371658295 5.2918425394165 CES1
ENSG00000227425 ENSG00000227425 4.90797507515821 5.69191001777592 5.29994254646707 NA
ENSG00000073754 ENSG00000073754 5.05869839771353 5.0382064256174 5.04845241166547 CD5L
ENSG00000163534 ENSG00000163534 5.17275132262055 5.16057170679365 5.1666615147071 FCRL1
ENSG00000132704 ENSG00000132704 5.20333662540855 5.02668368561451 5.11501015551153 FCRL2
ENSG00000248837 ENSG00000248837 5.45459712833339 5.2340626269356 5.3443298776345 LOC105374524
ENSG00000223756 ENSG00000223756 5.8137796438807 6.58085065215153 6.19731514801611 NA
ENSG00000228065 ENSG00000228065 5.9013462920888 5.67629893150035 5.78882261179458 NA
ENSG00000249948 ENSG00000249948 6.27363776230444 7.04452761048229 6.65908268639336 GBA3
ENSG00000105492 ENSG00000105492 2.94168223373985 2.88806561540889 2.91487392457437 SIGLEC6
ENSG00000173218 ENSG00000173218 3.11191964307186 2.959942454356 3.03593104871393 VANGL1
ENSG00000250107 ENSG00000250107 3.180800473785 3.01850158237708 3.09965102808104 CACNA1G-AS1
ENSG00000128274 ENSG00000128274 3.29622259074658 3.1243277128575 3.21027515180204 A4GALT
ENSG00000204460 ENSG00000204460 3.66131177483749 3.40876502389018 3.53503839936384 LINC01854

Reactome - Over Representation Analysis

The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.

Barplot

The most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.

Dotplot

The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.

Distributions of Log2FC

This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.

Gene-Concept Network

The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.

Enrich Map plot

The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.

Heatplot

Significant genes (x-axis) and the functional categories in which they appear.

Upsetplot

Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).

KEGG - Over Representation Analysis

The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.

Barplot

The most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.

Dotplot

The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.

Distributions of Log2FC

This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.

Gene-Concept Network

The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.

Enrich Map plot

The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.

Heatplot

Significant genes (x-axis) and the functional categories in which they appear.

Upsetplot

Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).

BP - Over Representation Analysis

The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.

Barplot

The most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.

Dotplot

The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.

Distributions of Log2FC

This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.

Gene-Concept Network

The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.

Enrich Map plot

The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.

Heatplot

Significant genes (x-axis) and the functional categories in which they appear.

Upsetplot

Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).

CC - Over Representation Analysis

The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.

Barplot

The most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.

Dotplot

The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.

Distributions of Log2FC

This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.

Gene-Concept Network

The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.

Enrich Map plot

The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.

Heatplot

Significant genes (x-axis) and the functional categories in which they appear.

Upsetplot

Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).

MF - Over Representation Analysis

The ORA method takes a group of significant genes and performs a Fisher's exact test for each term of the selected functional category.

Barplot

The most highly signficant categories in ascending order, according to adjusted p-value. The x-axis represents the number of significant genes found within the functional category.

Dotplot

The most highly signficant categories in descending in categories of gene ratio, defined as the proportion of significant genes that are found in the functional category. The x-axis represents the gene ratio and the dot size the number of genes associated with the functional category.

Distributions of Log2FC

This plot shows the distribution of gene Log2FC that enriched the top enriched functional term/pathways. The X axis repressent the distribution values. The color of the distribution repressents the FDR of the enrichment. The vertical lines represents the first, second and third quartiles.

Gene-Concept Network

The network connects the top functional categories (brown nodes) to their associated genes (grey or colored nodes). The size of the functional category nodes shows the number of connected genes.

Enrich Map plot

The top functional categories (nodes), connected if they share genes. Edge thickness represents the number of shared genes. Nodes size represents the number of significant genes within the category.

Heatplot

Significant genes (x-axis) and the functional categories in which they appear.

Upsetplot

Genes are clustered according to shared enriched categories. The y-axis shows the number of genes belonging to the different clusters (top) and categories to which they belong (bottom).

BP - Enrichments for Principal Components

Functional enrichments of PCs using all genes


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0002181 cytoplasmic translation 4.07e-18 NA 5.41e-05 NA
GO:0006412 translation 8.60e-08 NA 1.77e-03 NA
GO:0006119 oxidative phosphorylation 9.76e-07 NA NA NA
GO:0045333 cellular respiration 4.24e-06 NA NA NA
GO:0044419 biological process involved in interspec... 7.28e-06 NA NA NA
GO:0043207 response to external biotic stimulus 1.31e-05 NA NA NA
GO:0051707 response to other organism 1.31e-05 NA NA NA
GO:0006955 immune response 1.31e-05 NA NA NA
GO:1902600 proton transmembrane transport 2.93e-05 NA NA NA
GO:0009060 aerobic respiration 3.20e-05 NA NA NA
GO:0009607 response to biotic stimulus 3.41e-05 NA NA NA
GO:0019538 protein metabolic process 3.41e-05 NA NA NA
GO:0006508 proteolysis 3.98e-05 NA NA NA
GO:0006952 defense response 4.73e-05 NA NA NA
GO:0042773 ATP synthesis coupled electron transport 5.64e-05 NA NA NA
GO:0042775 mitochondrial ATP synthesis coupled elec... 5.64e-05 NA NA NA
GO:0022904 respiratory electron transport chain 6.86e-05 NA NA NA
GO:0002376 immune system process 7.79e-05 NA NA NA
GO:0002504 antigen processing and presentation of p... 9.25e-05 NA NA NA
GO:1990748 cellular detoxification 1.05e-04 NA NA NA
GO:0019882 antigen processing and presentation 1.05e-04 NA 6.38e-03 NA
GO:0002683 negative regulation of immune system pro... 1.31e-04 NA NA NA
GO:0048002 antigen processing and presentation of p... 1.36e-04 NA 1.15e-02 NA
GO:0019646 aerobic electron transport chain 1.38e-04 NA NA NA
GO:0006959 humoral immune response 1.45e-04 NA NA NA
GO:0097237 cellular response to toxic substance 1.45e-04 NA NA NA
GO:0001819 positive regulation of cytokine producti... 1.63e-04 NA NA NA
GO:0002495 antigen processing and presentation of p... 1.63e-04 NA 4.75e-02 NA
GO:0009605 response to external stimulus 2.14e-04 NA NA NA
GO:0051246 regulation of protein metabolic process 2.93e-04 NA NA NA
GO:0070431 nucleotide-binding oligomerization domai... 3.40e-04 NA NA NA
GO:0030162 regulation of proteolysis 3.40e-04 NA NA NA
GO:0002399 MHC class II protein complex assembly 3.40e-04 NA 6.28e-05 NA
GO:0002503 peptide antigen assembly with MHC class ... 3.40e-04 NA 6.28e-05 NA
GO:0022900 electron transport chain 3.40e-04 NA NA NA
GO:0030163 protein catabolic process 3.58e-04 NA NA NA
GO:0001906 cell killing 3.58e-04 NA 2.86e-02 NA
GO:0071634 regulation of transforming growth factor... 4.14e-04 NA NA NA
GO:0002698 negative regulation of immune effector p... 4.14e-04 NA NA NA
GO:0015980 energy derivation by oxidation of organi... 4.14e-04 NA NA NA
GO:0043069 negative regulation of programmed cell d... 5.04e-04 NA NA NA
GO:0007035 vacuolar acidification 9.04e-04 NA NA NA
GO:0051603 proteolysis involved in protein cataboli... 9.04e-04 NA NA NA
GO:0098754 detoxification 9.04e-04 NA NA NA
GO:0051452 intracellular pH reduction 9.09e-04 NA NA NA
GO:0140546 defense response to symbiont 9.09e-04 NA NA NA
GO:0001817 regulation of cytokine production 9.09e-04 NA NA NA
GO:0098542 defense response to other organism 9.09e-04 NA NA NA
GO:0110076 negative regulation of ferroptosis 9.09e-04 NA NA NA
GO:0098869 cellular oxidant detoxification 9.74e-04 NA NA NA
GO:0043066 negative regulation of apoptotic process 1.05e-03 NA NA NA
GO:0002437 inflammatory response to antigenic stimu... 1.10e-03 NA NA NA
GO:0019730 antimicrobial humoral response 1.10e-03 NA 1.89e-02 NA
GO:0061844 antimicrobial humoral immune response me... 1.10e-03 NA 7.20e-03 NA
GO:0045087 innate immune response 1.10e-03 NA NA NA
GO:0001816 cytokine production 1.14e-03 NA NA NA
GO:0090026 positive regulation of monocyte chemotax... 1.32e-03 NA NA NA
GO:0032543 mitochondrial translation 1.36e-03 NA NA NA
GO:0030003 intracellular monoatomic cation homeosta... 1.73e-03 NA NA NA
GO:0002710 negative regulation of T cell mediated i... 1.81e-03 NA NA NA
GO:0002682 regulation of immune system process 1.81e-03 NA NA NA
GO:0019886 antigen processing and presentation of e... 1.81e-03 NA 3.02e-02 NA
GO:1902956 regulation of mitochondrial electron tra... 1.87e-03 NA NA NA
GO:0002478 antigen processing and presentation of e... 1.89e-03 NA 1.72e-02 NA
GO:0030641 regulation of cellular pH 1.92e-03 NA NA NA
GO:0002548 monocyte chemotaxis 2.44e-03 NA NA NA
GO:0050868 negative regulation of T cell activation 2.67e-03 NA NA NA
GO:0006885 regulation of pH 2.94e-03 NA NA NA
GO:0051049 regulation of transport 2.97e-03 NA NA NA
GO:0006873 intracellular monoatomic ion homeostasis 3.22e-03 NA NA NA
GO:0050777 negative regulation of immune response 3.22e-03 NA NA NA
GO:1905446 regulation of mitochondrial ATP synthesi... 3.44e-03 NA NA NA
GO:0097401 synaptic vesicle lumen acidification 3.45e-03 NA NA NA
GO:0009617 response to bacterium 3.46e-03 NA NA NA
GO:0051453 regulation of intracellular pH 3.46e-03 NA NA NA
GO:0051050 positive regulation of transport 3.60e-03 NA NA NA
GO:0050817 coagulation 3.68e-03 NA NA NA
GO:0050776 regulation of immune response 3.78e-03 NA NA NA
GO:0097529 myeloid leukocyte migration 3.99e-03 NA NA NA
GO:0050866 negative regulation of cell activation 4.36e-03 NA NA NA
GO:0002237 response to molecule of bacterial origin 4.70e-03 NA NA NA
GO:0006954 inflammatory response 4.70e-03 NA NA NA
GO:0002687 positive regulation of leukocyte migrati... 4.71e-03 NA NA NA
GO:0019884 antigen processing and presentation of e... 4.72e-03 NA 3.51e-03 NA
GO:0032496 response to lipopolysaccharide 4.78e-03 NA NA NA
GO:0002697 regulation of immune effector process 4.78e-03 NA NA NA
GO:0097250 mitochondrial respirasome assembly 4.78e-03 NA NA NA
GO:0002250 adaptive immune response 4.89e-03 NA NA NA
GO:0042592 homeostatic process 4.99e-03 NA NA NA
GO:0042110 T cell activation 5.05e-03 NA NA NA
GO:0009057 macromolecule catabolic process 5.05e-03 NA NA NA
GO:0015986 proton motive force-driven ATP synthesis 5.05e-03 NA NA NA
GO:0006879 intracellular iron ion homeostasis 5.10e-03 NA NA NA
GO:0032613 interleukin-10 production 5.10e-03 NA NA NA
GO:0032653 regulation of interleukin-10 production 5.10e-03 NA NA NA
GO:0007596 blood coagulation 6.67e-03 NA NA NA
GO:1904063 negative regulation of cation transmembr... 6.69e-03 NA NA NA
GO:0016188 synaptic vesicle maturation 6.86e-03 NA NA NA
GO:0009636 response to toxic substance 6.86e-03 NA NA NA
GO:0002252 immune effector process 7.04e-03 NA NA NA
GO:0030309 poly-N-acetyllactosamine metabolic proce... 7.11e-03 NA NA NA
GO:0030311 poly-N-acetyllactosamine biosynthetic pr... 7.11e-03 NA NA NA
GO:0032101 regulation of response to external stimu... 7.11e-03 NA NA NA
GO:1903707 negative regulation of hemopoiesis 7.15e-03 NA NA NA
GO:0010628 positive regulation of gene expression 7.22e-03 NA NA NA
GO:0001775 cell activation 7.34e-03 NA NA NA
GO:0002396 MHC protein complex assembly 7.39e-03 NA 1.34e-03 NA
GO:0002501 peptide antigen assembly with MHC protei... 7.39e-03 NA 1.34e-03 NA
GO:1901652 response to peptide 7.43e-03 NA NA NA
GO:0006754 ATP biosynthetic process 7.43e-03 NA NA NA
GO:1901135 carbohydrate derivative metabolic proces... 7.51e-03 NA NA NA
GO:0036296 response to increased oxygen levels 7.53e-03 NA NA NA
GO:0002695 negative regulation of leukocyte activat... 7.53e-03 NA NA NA
GO:0042776 proton motive force-driven mitochondrial... 7.88e-03 NA NA NA
GO:0006091 generation of precursor metabolites and ... 7.88e-03 NA NA NA
GO:0002709 regulation of T cell mediated immunity 8.46e-03 NA NA NA
GO:0002685 regulation of leukocyte migration 8.46e-03 NA NA NA
GO:0031347 regulation of defense response 8.46e-03 NA NA NA
GO:0006121 mitochondrial electron transport, succin... 8.46e-03 NA NA NA
GO:0016050 vesicle organization 8.73e-03 NA NA NA
GO:0090025 regulation of monocyte chemotaxis 9.08e-03 NA NA NA
GO:0034097 response to cytokine 9.10e-03 NA NA NA
GO:0034109 homotypic cell-cell adhesion 9.14e-03 NA NA NA
GO:0002690 positive regulation of leukocyte chemota... 9.22e-03 NA NA NA
GO:0007042 lysosomal lumen acidification 9.26e-03 NA NA NA
GO:0055080 monoatomic cation homeostasis 9.32e-03 NA NA NA
GO:0035751 regulation of lysosomal lumen pH 9.34e-03 NA NA NA
GO:0031987 locomotion involved in locomotory behavi... 9.34e-03 NA NA NA
GO:2000767 positive regulation of cytoplasmic trans... 9.37e-03 NA NA NA
GO:0050801 monoatomic ion homeostasis 9.43e-03 NA NA NA
GO:0050900 leukocyte migration 9.79e-03 NA NA NA
GO:0007599 hemostasis 1.01e-02 NA NA NA
GO:0034374 low-density lipoprotein particle remodel... 1.03e-02 NA NA NA
GO:0006812 monoatomic cation transport 1.04e-02 NA NA NA
GO:0055082 intracellular chemical homeostasis 1.06e-02 NA NA NA
GO:0009611 response to wounding 1.11e-02 NA NA NA
GO:0002684 positive regulation of immune system pro... 1.16e-02 NA NA NA
GO:1902253 regulation of intrinsic apoptotic signal... 1.16e-02 NA NA NA
GO:0002424 T cell mediated immune response to tumor... 1.16e-02 NA NA NA
GO:0051250 negative regulation of lymphocyte activa... 1.19e-02 NA NA NA
GO:0045861 negative regulation of proteolysis 1.19e-02 NA NA NA
GO:0048524 positive regulation of viral process 1.19e-02 NA NA NA
GO:0033108 mitochondrial respiratory chain complex ... 1.19e-02 NA NA NA
GO:0048584 positive regulation of response to stimu... 1.23e-02 NA NA NA
GO:0043457 regulation of cellular respiration 1.24e-02 NA NA NA
GO:0042060 wound healing 1.24e-02 NA NA NA
GO:0002861 regulation of inflammatory response to a... 1.24e-02 NA NA NA
GO:0061077 chaperone-mediated protein folding 1.24e-02 NA NA NA
GO:0048227 plasma membrane to endosome transport 1.31e-02 NA NA NA
GO:1902106 negative regulation of leukocyte differe... 1.35e-02 NA NA NA
GO:0002831 regulation of response to biotic stimulu... 1.35e-02 NA NA NA
GO:0051248 negative regulation of protein metabolic... 1.35e-02 NA NA NA
GO:0002536 respiratory burst involved in inflammato... 1.36e-02 NA NA NA
GO:0038159 C-X-C chemokine receptor CXCR4 signaling... 1.41e-02 NA NA NA
GO:0023056 positive regulation of signaling 1.43e-02 NA NA NA
GO:0019941 modification-dependent protein catabolic... 1.43e-02 NA NA NA
GO:0019725 cellular homeostasis 1.44e-02 NA NA NA
GO:0032103 positive regulation of response to exter... 1.45e-02 NA NA NA
GO:0006123 mitochondrial electron transport, cytoch... 1.45e-02 NA NA NA
GO:0006511 ubiquitin-dependent protein catabolic pr... 1.50e-02 NA NA NA
GO:0032609 type II interferon production 1.53e-02 NA NA NA
GO:0032649 regulation of type II interferon product... 1.53e-02 NA NA NA
GO:1903038 negative regulation of leukocyte cell-ce... 1.56e-02 NA NA NA
GO:0002438 acute inflammatory response to antigenic... 1.56e-02 NA NA NA
GO:1902622 regulation of neutrophil migration 1.65e-02 NA NA NA
GO:0032757 positive regulation of interleukin-8 pro... 1.67e-02 NA NA NA
GO:0010647 positive regulation of cell communicatio... 1.68e-02 NA NA NA
GO:0070244 negative regulation of thymocyte apoptot... 1.69e-02 NA NA NA
GO:0071604 transforming growth factor beta producti... 1.70e-02 NA NA NA
GO:0051604 protein maturation 1.75e-02 NA NA NA
GO:0052547 regulation of peptidase activity 1.82e-02 NA NA NA
GO:0032733 positive regulation of interleukin-10 pr... 1.82e-02 NA NA NA
GO:0006413 translational initiation 1.82e-02 NA 3.57e-02 NA
GO:0140053 mitochondrial gene expression 1.86e-02 NA NA NA
GO:0051051 negative regulation of transport 1.92e-02 NA NA NA
GO:1902624 positive regulation of neutrophil migrat... 1.98e-02 NA NA NA
GO:0009145 purine nucleoside triphosphate biosynthe... 2.05e-02 NA NA NA
GO:0098662 inorganic cation transmembrane transport 2.05e-02 NA NA NA
GO:0070527 platelet aggregation 2.05e-02 NA NA NA
GO:0070432 regulation of nucleotide-binding oligome... 2.05e-02 NA NA NA
GO:0010498 proteasomal protein catabolic process 2.05e-02 NA NA NA
GO:0007159 leukocyte cell-cell adhesion 2.05e-02 NA NA NA
GO:0002286 T cell activation involved in immune res... 2.14e-02 NA NA NA
GO:0045321 leukocyte activation 2.17e-02 NA NA NA
GO:0032689 negative regulation of type II interfero... 2.17e-02 NA NA NA
GO:0019883 antigen processing and presentation of e... 2.17e-02 NA 7.05e-03 NA
GO:0071345 cellular response to cytokine stimulus 2.23e-02 NA NA NA
GO:0002688 regulation of leukocyte chemotaxis 2.23e-02 NA NA NA
GO:0032944 regulation of mononuclear cell prolifera... 2.26e-02 NA NA NA
GO:0042274 ribosomal small subunit biogenesis 2.26e-02 NA NA NA
GO:0007220 Notch receptor processing 2.28e-02 NA NA NA
GO:0002707 negative regulation of lymphocyte mediat... 2.28e-02 NA NA NA
GO:0001909 leukocyte mediated cytotoxicity 2.28e-02 NA NA NA
GO:0022408 negative regulation of cell-cell adhesio... 2.28e-02 NA NA NA
GO:0034766 negative regulation of monoatomic ion tr... 2.28e-02 NA NA NA
GO:0043632 modification-dependent macromolecule cat... 2.29e-02 NA NA NA
GO:0002862 negative regulation of inflammatory resp... 2.31e-02 NA NA NA
GO:0009206 purine ribonucleoside triphosphate biosy... 2.31e-02 NA NA NA
GO:0031348 negative regulation of defense response 2.32e-02 NA NA NA
GO:0050670 regulation of lymphocyte proliferation 2.33e-02 NA NA NA
GO:0043067 regulation of programmed cell death 2.34e-02 NA NA NA
GO:0002840 regulation of T cell mediated immune res... 2.36e-02 NA NA NA
GO:0042129 regulation of T cell proliferation 2.37e-02 NA NA NA
GO:0042127 regulation of cell population proliferat... 2.37e-02 NA NA NA
GO:0002456 T cell mediated immunity 2.40e-02 NA NA NA
GO:0002367 cytokine production involved in immune r... 2.44e-02 NA NA NA
GO:0002718 regulation of cytokine production involv... 2.44e-02 NA NA NA
GO:0002443 leukocyte mediated immunity 2.46e-02 NA NA NA
GO:0042221 response to chemical 2.47e-02 NA NA NA
GO:2001258 negative regulation of cation channel ac... 2.55e-02 NA NA NA
GO:0046649 lymphocyte activation 2.55e-02 NA NA NA
GO:2001234 negative regulation of apoptotic signali... 2.55e-02 NA NA NA
GO:0006956 complement activation 2.57e-02 NA NA NA
GO:0071706 tumor necrosis factor superfamily cytoki... 2.60e-02 NA NA NA
GO:1903555 regulation of tumor necrosis factor supe... 2.60e-02 NA NA NA
GO:0032879 regulation of localization 2.60e-02 NA NA NA
GO:0050778 positive regulation of immune response 2.60e-02 NA NA NA
GO:0071492 cellular response to UV-A 2.60e-02 NA NA NA
GO:0002704 negative regulation of leukocyte mediate... 2.65e-02 NA NA NA
GO:0009056 catabolic process 2.65e-02 NA NA NA
GO:0001913 T cell mediated cytotoxicity 2.70e-02 NA NA NA
GO:0048878 chemical homeostasis 2.73e-02 NA NA NA
GO:0070663 regulation of leukocyte proliferation 2.73e-02 NA NA NA
GO:0065008 regulation of biological quality 2.73e-02 NA NA NA
GO:0071878 negative regulation of adenylate cyclase... 2.82e-02 NA NA NA
GO:0007162 negative regulation of cell adhesion 2.83e-02 NA NA NA
GO:0050765 negative regulation of phagocytosis 2.88e-02 NA NA NA
GO:0006465 signal peptide processing 2.88e-02 NA NA NA
GO:0009967 positive regulation of signal transducti... 2.88e-02 NA NA NA
GO:0061450 trophoblast cell migration 2.93e-02 NA NA NA
GO:1901163 regulation of trophoblast cell migration 2.93e-02 NA NA NA
GO:0042744 hydrogen peroxide catabolic process 2.95e-02 NA NA NA
GO:0060231 mesenchymal to epithelial transition 2.99e-02 NA NA NA
GO:0006968 cellular defense response 2.99e-02 NA NA NA
GO:0015734 taurine transmembrane transport 2.99e-02 NA NA NA
GO:0042918 alkanesulfonate transmembrane transport 2.99e-02 NA NA NA
GO:0034762 regulation of transmembrane transport 2.99e-02 NA NA NA
GO:0008284 positive regulation of cell population p... 3.00e-02 NA NA NA
GO:2001242 regulation of intrinsic apoptotic signal... 3.11e-02 NA 3.47e-02 NA
GO:0097212 lysosomal membrane organization 3.16e-02 NA NA NA
GO:0007005 mitochondrion organization 3.16e-02 NA NA NA
GO:0038061 non-canonical NF-kappaB signal transduct... 3.18e-02 NA NA NA
GO:0018958 phenol-containing compound metabolic pro... 3.24e-02 NA NA NA
GO:0032943 mononuclear cell proliferation 3.24e-02 NA NA NA
GO:0060479 lung cell differentiation 3.24e-02 NA NA NA
GO:0060487 lung epithelial cell differentiation 3.24e-02 NA NA NA
GO:0031647 regulation of protein stability 3.25e-02 NA NA NA
GO:0050727 regulation of inflammatory response 3.25e-02 NA NA NA
GO:1903320 regulation of protein modification by sm... 3.30e-02 NA NA NA
GO:0060054 positive regulation of epithelial cell p... 3.36e-02 NA NA NA
GO:0071636 positive regulation of transforming grow... 3.43e-02 NA NA NA
GO:0007040 lysosome organization 3.51e-02 NA NA NA
GO:0080171 lytic vacuole organization 3.51e-02 NA NA NA
GO:0042981 regulation of apoptotic process 3.57e-02 NA NA NA
GO:0098609 cell-cell adhesion 3.57e-02 NA 4.52e-02 NA
GO:0007032 endosome organization 3.67e-02 NA NA NA
GO:0031638 zymogen activation 3.67e-02 NA NA NA
GO:0032640 tumor necrosis factor production 3.88e-02 NA NA NA
GO:0032680 regulation of tumor necrosis factor prod... 3.88e-02 NA NA NA
GO:0006958 complement activation, classical pathway 3.94e-02 NA NA NA
GO:0046651 lymphocyte proliferation 4.07e-02 NA NA NA
GO:2001233 regulation of apoptotic signaling pathwa... 4.09e-02 NA NA NA
GO:0002449 lymphocyte mediated immunity 4.12e-02 NA NA NA
GO:0043161 proteasome-mediated ubiquitin-dependent ... 4.12e-02 NA NA NA
GO:1903037 regulation of leukocyte cell-cell adhesi... 4.12e-02 NA NA NA
GO:1903911 positive regulation of receptor clusteri... 4.13e-02 NA NA NA
GO:0003015 heart process 4.13e-02 NA NA NA
GO:0019076 viral release from host cell 4.13e-02 NA NA NA
GO:0035891 exit from host cell 4.13e-02 NA NA NA
GO:0098655 monoatomic cation transmembrane transpor... 4.13e-02 NA NA NA
GO:0006120 mitochondrial electron transport, NADH t... 4.14e-02 NA NA NA
GO:2001257 regulation of cation channel activity 4.16e-02 NA NA NA
GO:1903170 negative regulation of calcium ion trans... 4.18e-02 NA NA NA
GO:1903715 regulation of aerobic respiration 4.20e-02 NA NA NA
GO:0032906 transforming growth factor beta2 product... 4.20e-02 NA NA NA
GO:0032909 regulation of transforming growth factor... 4.20e-02 NA NA NA
GO:0016485 protein processing 4.20e-02 NA NA NA
GO:0045088 regulation of innate immune response 4.26e-02 NA NA NA
GO:0031341 regulation of cell killing 4.30e-02 NA NA NA
GO:0042373 vitamin K metabolic process 4.33e-02 NA NA NA
GO:0031349 positive regulation of defense response 4.33e-02 NA NA NA
GO:0070434 positive regulation of nucleotide-bindin... 4.33e-02 NA NA NA
GO:0050865 regulation of cell activation 4.37e-02 NA NA NA
GO:0090022 regulation of neutrophil chemotaxis 4.39e-02 NA NA NA
GO:1901857 positive regulation of cellular respirat... 4.49e-02 NA NA NA
GO:1900044 regulation of protein K63-linked ubiquit... 4.49e-02 NA NA NA
GO:0016032 viral process 4.57e-02 NA NA NA
GO:0052548 regulation of endopeptidase activity 4.58e-02 NA NA NA
GO:0044403 biological process involved in symbiotic... 4.65e-02 NA NA NA
GO:0036295 cellular response to increased oxygen le... 4.65e-02 NA NA NA
GO:0031640 killing of cells of another organism 4.65e-02 NA 6.64e-03 NA
GO:0141061 disruption of cell in another organism 4.65e-02 NA 6.64e-03 NA
GO:1901873 regulation of post-translational protein... 4.66e-02 NA NA NA
GO:2001188 regulation of T cell activation via T ce... 4.66e-02 NA NA NA
GO:0050863 regulation of T cell activation 4.80e-02 NA 3.57e-02 NA
GO:0002460 adaptive immune response based on somati... 4.80e-02 NA NA NA
GO:0006325 chromatin organization NA 1.08e-12 2.90e-06 NA
GO:0006338 chromatin remodeling NA 3.29e-11 1.28e-07 NA
GO:0006261 DNA-templated DNA replication NA 5.97e-10 4.03e-04 NA
GO:0006281 DNA repair NA 8.65e-09 1.87e-03 NA
GO:0006974 DNA damage response NA 1.66e-08 3.90e-03 NA
GO:0090304 nucleic acid metabolic process NA 3.76e-08 1.87e-02 NA
GO:0006260 DNA replication NA 9.19e-08 1.01e-05 NA
GO:0006259 DNA metabolic process NA 3.97e-07 3.04e-04 NA
GO:0006139 nucleobase-containing compound metabolic... NA 3.97e-07 NA NA
GO:0006302 double-strand break repair NA 6.59e-07 9.66e-05 NA
GO:0022402 cell cycle process NA 9.61e-07 1.12e-11 NA
GO:0007049 cell cycle NA 4.34e-06 1.12e-11 NA
GO:0010564 regulation of cell cycle process NA 6.53e-06 1.53e-10 NA
GO:0019219 regulation of nucleobase-containing comp... NA 2.00e-05 NA NA
GO:0098534 centriole assembly NA 1.50e-04 NA NA
GO:0033260 nuclear DNA replication NA 2.40e-04 NA NA
GO:0051276 chromosome organization NA 2.55e-04 8.29e-14 NA
GO:0016043 cellular component organization NA 2.55e-04 3.16e-03 NA
GO:0007010 cytoskeleton organization NA 3.31e-04 NA NA
GO:2001141 regulation of RNA biosynthetic process NA 3.31e-04 NA NA
GO:0006355 regulation of DNA-templated transcriptio... NA 3.31e-04 NA NA
GO:0051726 regulation of cell cycle NA 3.97e-04 1.60e-10 NA
GO:0051056 regulation of small GTPase mediated sign... NA 3.97e-04 NA NA
GO:0051252 regulation of RNA metabolic process NA 5.11e-04 NA NA
GO:0045005 DNA-templated DNA replication maintenanc... NA 5.17e-04 2.87e-02 NA
GO:0044786 cell cycle DNA replication NA 6.13e-04 2.93e-02 NA
GO:0007099 centriole replication NA 6.60e-04 NA NA
GO:0006351 DNA-templated transcription NA 6.84e-04 NA NA
GO:0141187 nucleic acid biosynthetic process NA 8.04e-04 NA NA
GO:0000727 double-strand break repair via break-ind... NA 8.91e-04 NA NA
GO:0045935 positive regulation of nucleobase-contai... NA 8.91e-04 4.75e-02 NA
GO:0006366 transcription by RNA polymerase II NA 8.91e-04 NA NA
GO:0000278 mitotic cell cycle NA 1.05e-03 2.32e-12 NA
GO:0016070 RNA metabolic process NA 1.05e-03 NA NA
GO:0006269 DNA replication, synthesis of primer NA 1.05e-03 NA NA
GO:0006357 regulation of transcription by RNA polym... NA 1.33e-03 NA NA
GO:0051052 regulation of DNA metabolic process NA 1.37e-03 1.04e-04 NA
GO:0034654 nucleobase-containing compound biosynthe... NA 1.55e-03 NA NA
GO:0051298 centrosome duplication NA 1.90e-03 NA NA
GO:0071840 cellular component organization or bioge... NA 2.21e-03 3.60e-04 NA
GO:1903047 mitotic cell cycle process NA 2.25e-03 1.12e-11 NA
GO:0090329 regulation of DNA-templated DNA replicat... NA 2.30e-03 NA NA
GO:0032774 RNA biosynthetic process NA 2.70e-03 NA NA
GO:0007098 centrosome cycle NA 2.84e-03 NA NA
GO:0000226 microtubule cytoskeleton organization NA 2.84e-03 1.26e-04 NA
GO:0031023 microtubule organizing center organizati... NA 2.84e-03 NA NA
GO:0000724 double-strand break repair via homologou... NA 2.84e-03 2.07e-02 NA
GO:0000725 recombinational repair NA 2.84e-03 1.61e-02 NA
GO:0034983 peptidyl-lysine deacetylation NA 2.84e-03 NA NA
GO:1901987 regulation of cell cycle phase transitio... NA 3.16e-03 2.99e-07 NA
GO:0000076 DNA replication checkpoint signaling NA 3.65e-03 NA NA
GO:0018126 protein hydroxylation NA 5.25e-03 NA NA
GO:0006282 regulation of DNA repair NA 5.25e-03 6.03e-03 NA
GO:0007017 microtubule-based process NA 5.25e-03 9.83e-04 NA
GO:0051254 positive regulation of RNA metabolic pro... NA 5.63e-03 NA NA
GO:0006270 DNA replication initiation NA 5.73e-03 NA NA
GO:0045786 negative regulation of cell cycle NA 7.77e-03 2.81e-06 NA
GO:0031297 replication fork processing NA 8.33e-03 4.66e-02 NA
GO:0051054 positive regulation of DNA metabolic pro... NA 8.78e-03 3.91e-03 NA
GO:1900262 regulation of DNA-directed DNA polymeras... NA 9.38e-03 NA NA
GO:1900264 positive regulation of DNA-directed DNA ... NA 9.38e-03 NA NA
GO:0032886 regulation of microtubule-based process NA 1.08e-02 NA NA
GO:0006996 organelle organization NA 1.23e-02 3.01e-02 NA
GO:0036297 interstrand cross-link repair NA 1.30e-02 NA NA
GO:0030174 regulation of DNA-templated DNA replicat... NA 1.31e-02 NA NA
GO:0045893 positive regulation of DNA-templated tra... NA 1.34e-02 NA NA
GO:1902680 positive regulation of RNA biosynthetic ... NA 1.45e-02 NA NA
GO:2000779 regulation of double-strand break repair NA 1.46e-02 3.27e-04 NA
GO:0044782 cilium organization NA 1.61e-02 NA NA
GO:0010948 negative regulation of cell cycle proces... NA 1.62e-02 4.08e-06 NA
GO:0006310 DNA recombination NA 1.69e-02 4.82e-03 NA
GO:0032259 methylation NA 1.81e-02 NA NA
GO:0051984 positive regulation of chromosome segreg... NA 2.40e-02 1.22e-03 NA
GO:0000075 cell cycle checkpoint signaling NA 2.94e-02 4.29e-04 NA
GO:0040029 epigenetic regulation of gene expression NA 2.94e-02 2.45e-03 NA
GO:0006013 mannose metabolic process NA 3.28e-02 NA NA
GO:0060271 cilium assembly NA 3.61e-02 NA NA
GO:0033043 regulation of organelle organization NA 3.61e-02 1.31e-02 NA
GO:0046985 positive regulation of hemoglobin biosyn... NA 3.61e-02 NA NA
GO:0006312 mitotic recombination NA 3.76e-02 NA NA
GO:0009190 cyclic nucleotide biosynthetic process NA 3.79e-02 NA NA
GO:0044770 cell cycle phase transition NA 3.81e-02 1.60e-06 NA
GO:1901990 regulation of mitotic cell cycle phase t... NA 4.10e-02 5.50e-07 NA
GO:0046777 protein autophosphorylation NA 4.10e-02 NA NA
GO:1902017 regulation of cilium assembly NA 4.65e-02 NA NA
GO:1903251 multi-ciliated epithelial cell different... NA 4.67e-02 NA NA
GO:1901988 negative regulation of cell cycle phase ... NA 4.87e-02 2.30e-05 NA
GO:0007059 chromosome segregation NA NA 1.05e-12 NA
GO:0000819 sister chromatid segregation NA NA 1.12e-11 NA
GO:0000280 nuclear division NA NA 1.12e-11 NA
GO:0034728 nucleosome organization NA NA 1.89e-11 NA
GO:0098813 nuclear chromosome segregation NA NA 2.16e-11 NA
GO:0006334 nucleosome assembly NA NA 1.46e-10 NA
GO:0071824 protein-DNA complex organization NA NA 1.53e-10 NA
GO:0140014 mitotic nuclear division NA NA 2.05e-10 NA
GO:0000070 mitotic sister chromatid segregation NA NA 4.24e-10 NA
GO:0065004 protein-DNA complex assembly NA NA 1.84e-09 NA
GO:0048285 organelle fission NA NA 2.00e-09 NA
GO:0007346 regulation of mitotic cell cycle NA NA 9.90e-09 NA
GO:0051301 cell division NA NA 2.09e-08 NA
GO:0051983 regulation of chromosome segregation NA NA 2.53e-08 NA
GO:0033045 regulation of sister chromatid segregati... NA NA 6.11e-07 NA
GO:1902099 regulation of metaphase/anaphase transit... NA NA 1.43e-06 NA
GO:0030071 regulation of mitotic metaphase/anaphase... NA NA 1.86e-06 NA
GO:0033047 regulation of mitotic sister chromatid s... NA NA 2.24e-06 NA
GO:0090068 positive regulation of cell cycle proces... NA NA 2.76e-06 NA
GO:0044784 metaphase/anaphase transition of cell cy... NA NA 3.07e-06 NA
GO:0044772 mitotic cell cycle phase transition NA NA 3.97e-06 NA
GO:0007091 metaphase/anaphase transition of mitotic... NA NA 3.97e-06 NA
GO:0045839 negative regulation of mitotic nuclear d... NA NA 4.24e-06 NA
GO:0051985 negative regulation of chromosome segreg... NA NA 6.09e-06 NA
GO:0140694 non-membrane-bounded organelle assembly NA NA 1.01e-05 NA
GO:1902100 negative regulation of metaphase/anaphas... NA NA 1.15e-05 NA
GO:1905819 negative regulation of chromosome separa... NA NA 1.15e-05 NA
GO:0033046 negative regulation of sister chromatid ... NA NA 1.59e-05 NA
GO:0033048 negative regulation of mitotic sister ch... NA NA 1.59e-05 NA
GO:0045841 negative regulation of mitotic metaphase... NA NA 1.59e-05 NA
GO:2000816 negative regulation of mitotic sister ch... NA NA 1.59e-05 NA
GO:1905818 regulation of chromosome separation NA NA 1.81e-05 NA
GO:0033044 regulation of chromosome organization NA NA 2.25e-05 NA
GO:0051304 chromosome separation NA NA 2.47e-05 NA
GO:0007088 regulation of mitotic nuclear division NA NA 3.36e-05 NA
GO:0031577 spindle checkpoint signaling NA NA 3.88e-05 NA
GO:0007052 mitotic spindle organization NA NA 4.77e-05 NA
GO:0045930 negative regulation of mitotic cell cycl... NA NA 4.85e-05 NA
GO:0007094 mitotic spindle assembly checkpoint sign... NA NA 5.31e-05 NA
GO:0071173 spindle assembly checkpoint signaling NA NA 5.31e-05 NA
GO:0071174 mitotic spindle checkpoint signaling NA NA 5.31e-05 NA
GO:0051784 negative regulation of nuclear division NA NA 6.58e-05 NA
GO:0030261 chromosome condensation NA NA 8.70e-05 NA
GO:0080135 regulation of cellular response to stres... NA NA 9.03e-05 NA
GO:0071459 protein localization to chromosome, cent... NA NA 9.66e-05 NA
GO:0051783 regulation of nuclear division NA NA 9.68e-05 NA
GO:0051306 mitotic sister chromatid separation NA NA 1.13e-04 NA
GO:0045787 positive regulation of cell cycle NA NA 1.13e-04 NA
GO:1902850 microtubule cytoskeleton organization in... NA NA 1.26e-04 NA
GO:0051303 establishment of chromosome localization NA NA 1.79e-04 NA
GO:0140013 meiotic nuclear division NA NA 1.88e-04 NA
GO:0007051 spindle organization NA NA 1.88e-04 NA
GO:0010965 regulation of mitotic sister chromatid s... NA NA 2.06e-04 NA
GO:0008608 attachment of spindle microtubules to ki... NA NA 2.79e-04 NA
GO:0050000 chromosome localization NA NA 2.95e-04 NA
GO:0051225 spindle assembly NA NA 3.09e-04 NA
GO:0044085 cellular component biogenesis NA NA 3.14e-04 NA
GO:2001251 negative regulation of chromosome organi... NA NA 3.27e-04 NA
GO:0051310 metaphase chromosome alignment NA NA 5.21e-04 NA
GO:2000781 positive regulation of double-strand bre... NA NA 5.38e-04 NA
GO:1901976 regulation of cell cycle checkpoint NA NA 8.14e-04 NA
GO:0051988 regulation of attachment of spindle micr... NA NA 8.66e-04 NA
GO:1901991 negative regulation of mitotic cell cycl... NA NA 1.01e-03 NA
GO:0008156 negative regulation of DNA replication NA NA 1.02e-03 NA
GO:1903046 meiotic cell cycle process NA NA 1.34e-03 NA
GO:0007093 mitotic cell cycle checkpoint signaling NA NA 1.45e-03 NA
GO:0045739 positive regulation of DNA repair NA NA 1.45e-03 NA
GO:0043933 protein-containing complex organization NA NA 1.59e-03 NA
GO:0034502 protein localization to chromosome NA NA 1.94e-03 NA
GO:0051321 meiotic cell cycle NA NA 2.12e-03 NA
GO:0031392 regulation of prostaglandin biosynthetic... NA NA 2.12e-03 NA
GO:1902751 positive regulation of cell cycle G2/M p... NA NA 2.34e-03 NA
GO:0010569 regulation of double-strand break repair... NA NA 2.35e-03 NA
GO:0065003 protein-containing complex assembly NA NA 2.40e-03 NA
GO:0042254 ribosome biogenesis NA NA 2.59e-03 NA
GO:0045814 negative regulation of gene expression, ... NA NA 2.77e-03 NA
GO:0051315 attachment of mitotic spindle microtubul... NA NA 3.25e-03 NA
GO:0051955 regulation of amino acid transport NA NA 3.31e-03 NA
GO:0061644 protein localization to CENP-A containin... NA NA 3.39e-03 NA
GO:0031507 heterochromatin formation NA NA 3.80e-03 NA
GO:0090307 mitotic spindle assembly NA NA 4.00e-03 NA
GO:0000018 regulation of DNA recombination NA NA 4.05e-03 NA
GO:0022607 cellular component assembly NA NA 4.05e-03 NA
GO:0000022 mitotic spindle elongation NA NA 4.12e-03 NA
GO:0051251 positive regulation of lymphocyte activa... NA NA 4.24e-03 NA
GO:0033554 cellular response to stress NA NA 4.24e-03 NA
GO:0051256 mitotic spindle midzone assembly NA NA 4.55e-03 NA
GO:0097190 apoptotic signaling pathway NA NA 4.79e-03 NA
GO:0051302 regulation of cell division NA NA 5.06e-03 NA
GO:0010971 positive regulation of G2/M transition o... NA NA 5.06e-03 NA
GO:0051231 spindle elongation NA NA 5.21e-03 NA
GO:0022613 ribonucleoprotein complex biogenesis NA NA 5.29e-03 NA
GO:0071479 cellular response to ionizing radiation NA NA 5.66e-03 NA
GO:0070059 intrinsic apoptotic signaling pathway in... NA NA 6.03e-03 NA
GO:0019731 antibacterial humoral response NA NA 6.38e-03 NA
GO:0061982 meiosis I cell cycle process NA NA 7.29e-03 NA
GO:0022409 positive regulation of cell-cell adhesio... NA NA 8.12e-03 NA
GO:0007080 mitotic metaphase chromosome alignment NA NA 8.14e-03 NA
GO:0034085 establishment of sister chromatid cohesi... NA NA 8.14e-03 NA
GO:0097193 intrinsic apoptotic signaling pathway NA NA 8.69e-03 NA
GO:0032890 regulation of organic acid transport NA NA 9.09e-03 NA
GO:0010639 negative regulation of organelle organiz... NA NA 9.11e-03 NA
GO:0030073 insulin secretion NA NA 9.14e-03 NA
GO:0050870 positive regulation of T cell activation NA NA 9.25e-03 NA
GO:0048522 positive regulation of cellular process NA NA 1.01e-02 NA
GO:0014049 positive regulation of glutamate secreti... NA NA 1.02e-02 NA
GO:0160049 negative regulation of cGAS/STING signal... NA NA 1.04e-02 NA
GO:0045132 meiotic chromosome segregation NA NA 1.15e-02 NA
GO:0071362 cellular response to ether NA NA 1.15e-02 NA
GO:0000082 G1/S transition of mitotic cell cycle NA NA 1.16e-02 NA
GO:0140896 cGAS/STING signaling pathway NA NA 1.17e-02 NA
GO:0051255 spindle midzone assembly NA NA 1.21e-02 NA
GO:0007076 mitotic chromosome condensation NA NA 1.33e-02 NA
GO:0014048 regulation of glutamate secretion NA NA 1.34e-02 NA
GO:0002696 positive regulation of leukocyte activat... NA NA 1.45e-02 NA
GO:0034508 centromere complex assembly NA NA 1.47e-02 NA
GO:2000045 regulation of G1/S transition of mitotic... NA NA 1.53e-02 NA
GO:0001945 lymph vessel development NA NA 1.61e-02 NA
GO:0016072 rRNA metabolic process NA NA 1.62e-02 NA
GO:0062029 positive regulation of stress granule as... NA NA 1.62e-02 NA
GO:0051249 regulation of lymphocyte activation NA NA 1.68e-02 NA
GO:0006337 nucleosome disassembly NA NA 1.69e-02 NA
GO:0006275 regulation of DNA replication NA NA 1.69e-02 NA
GO:0022407 regulation of cell-cell adhesion NA NA 1.70e-02 NA
GO:0044771 meiotic cell cycle phase transition NA NA 1.74e-02 NA
GO:1901989 positive regulation of cell cycle phase ... NA NA 1.80e-02 NA
GO:0032986 protein-DNA complex disassembly NA NA 1.81e-02 NA
GO:0015833 peptide transport NA NA 1.87e-02 NA
GO:0030072 peptide hormone secretion NA NA 1.87e-02 NA
GO:0050867 positive regulation of cell activation NA NA 1.89e-02 NA
GO:0071168 protein localization to chromatin NA NA 1.96e-02 NA
GO:0044843 cell cycle G1/S phase transition NA NA 2.03e-02 NA
GO:0002790 peptide secretion NA NA 2.04e-02 NA
GO:0002791 regulation of peptide secretion NA NA 2.04e-02 NA
GO:0090087 regulation of peptide transport NA NA 2.04e-02 NA
GO:1902423 regulation of attachment of mitotic spin... NA NA 2.18e-02 NA
GO:0051956 negative regulation of amino acid transp... NA NA 2.18e-02 NA
GO:0043382 positive regulation of memory T cell dif... NA NA 2.28e-02 NA
GO:0060623 regulation of chromosome condensation NA NA 2.36e-02 NA
GO:1903039 positive regulation of leukocyte cell-ce... NA NA 2.36e-02 NA
GO:0007019 microtubule depolymerization NA NA 2.36e-02 NA
GO:1902806 regulation of cell cycle G1/S phase tran... NA NA 2.38e-02 NA
GO:0007127 meiosis I NA NA 2.61e-02 NA
GO:0050830 defense response to Gram-positive bacter... NA NA 2.64e-02 NA
GO:2001244 positive regulation of intrinsic apoptot... NA NA 2.64e-02 NA
GO:0009059 macromolecule biosynthetic process NA NA 2.64e-02 NA
GO:0051053 negative regulation of DNA metabolic pro... NA NA 2.64e-02 NA
GO:0008219 cell death NA NA 2.64e-02 NA
GO:0034975 protein folding in endoplasmic reticulum NA NA 2.71e-02 NA
GO:0006303 double-strand break repair via nonhomolo... NA NA 2.71e-02 NA
GO:0006364 rRNA processing NA NA 2.71e-02 NA
GO:0099174 regulation of presynapse organization NA NA 2.72e-02 NA
GO:1905606 regulation of presynapse assembly NA NA 2.72e-02 NA
GO:1901992 positive regulation of mitotic cell cycl... NA NA 2.83e-02 NA
GO:0048518 positive regulation of biological proces... NA NA 2.97e-02 NA
GO:0048245 eosinophil chemotaxis NA NA 3.01e-02 NA
GO:0090231 regulation of spindle checkpoint NA NA 3.02e-02 NA
GO:0043331 response to dsRNA NA NA 3.02e-02 NA
GO:0002483 antigen processing and presentation of e... NA NA 3.05e-02 NA
GO:0097278 complement-dependent cytotoxicity NA NA 3.17e-02 NA
GO:0090276 regulation of peptide hormone secretion NA NA 3.17e-02 NA
GO:0034087 establishment of mitotic sister chromati... NA NA 3.17e-02 NA
GO:1902459 positive regulation of stem cell populat... NA NA 3.18e-02 NA
GO:0072677 eosinophil migration NA NA 3.19e-02 NA
GO:2000669 negative regulation of dendritic cell ap... NA NA 3.22e-02 NA
GO:1905821 positive regulation of chromosome conden... NA NA 3.22e-02 NA
GO:0045653 negative regulation of megakaryocyte dif... NA NA 3.22e-02 NA
GO:0032465 regulation of cytokinesis NA NA 3.22e-02 NA
GO:0071692 protein localization to extracellular re... NA NA 3.27e-02 NA
GO:0098937 anterograde dendritic transport NA NA 3.29e-02 NA
GO:0000375 RNA splicing, via transesterification re... NA NA 3.29e-02 NA
GO:0007143 female meiotic nuclear division NA NA 3.33e-02 NA
GO:0010829 negative regulation of D-glucose transme... NA NA 3.44e-02 NA
GO:0035592 establishment of protein localization to... NA NA 3.54e-02 NA
GO:1905820 positive regulation of chromosome separa... NA NA 3.54e-02 NA
GO:2001235 positive regulation of apoptotic signali... NA NA 3.66e-02 NA
GO:1901993 regulation of meiotic cell cycle phase t... NA NA 3.69e-02 NA
GO:0045934 negative regulation of nucleobase-contai... NA NA 3.71e-02 NA
GO:0080134 regulation of response to stress NA NA 3.91e-02 NA
GO:0006997 nucleus organization NA NA 3.92e-02 NA
GO:0051307 meiotic chromosome separation NA NA 3.92e-02 NA
GO:0042104 positive regulation of activated T cell ... NA NA 3.96e-02 NA
GO:0012501 programmed cell death NA NA 4.01e-02 NA
GO:0009306 protein secretion NA NA 4.12e-02 NA
GO:0032075 positive regulation of nuclease activity NA NA 4.20e-02 NA
GO:0032467 positive regulation of cytokinesis NA NA 4.20e-02 NA
GO:0090266 regulation of mitotic cell cycle spindle... NA NA 4.40e-02 NA
GO:1903504 regulation of mitotic spindle checkpoint NA NA 4.40e-02 NA
GO:0097421 liver regeneration NA NA 4.40e-02 NA
GO:0032071 regulation of endodeoxyribonuclease acti... NA NA 4.47e-02 NA
GO:0050796 regulation of insulin secretion NA NA 4.47e-02 NA
GO:0031055 chromatin remodeling at centromere NA NA 4.47e-02 NA
GO:0034080 CENP-A containing chromatin assembly NA NA 4.47e-02 NA
GO:0045910 negative regulation of DNA recombination NA NA 4.47e-02 NA
GO:0071868 cellular response to monoamine stimulus NA NA 4.47e-02 NA
GO:0071870 cellular response to catecholamine stimu... NA NA 4.47e-02 NA
GO:1903350 response to dopamine NA NA 4.47e-02 NA
GO:0044806 G-quadruplex DNA unwinding NA NA 4.52e-02 NA
GO:0098971 anterograde dendritic transport of neuro... NA NA 4.55e-02 NA
GO:0071359 cellular response to dsRNA NA NA 4.64e-02 NA
GO:0071103 DNA conformation change NA NA 4.72e-02 NA
GO:0021999 neural plate anterior/posterior regional... NA NA 4.75e-02 NA
GO:0006915 apoptotic process NA NA 4.75e-02 NA
GO:0007062 sister chromatid cohesion NA NA 4.75e-02 NA
GO:0042273 ribosomal large subunit biogenesis NA NA 4.75e-02 NA
GO:0032392 DNA geometric change NA NA 4.75e-02 NA
GO:0006271 DNA strand elongation involved in DNA re... NA NA 4.75e-02 NA
GO:0010389 regulation of G2/M transition of mitotic... NA NA 4.75e-02 NA
GO:2001293 malonyl-CoA metabolic process NA NA 4.79e-02 NA
GO:0001946 lymphangiogenesis NA NA 4.79e-02 NA
GO:0045911 positive regulation of DNA recombination NA NA 4.79e-02 NA
GO:2000036 regulation of stem cell population maint... NA NA 4.79e-02 NA
GO:2000330 positive regulation of T-helper 17 cell ... NA NA 4.91e-02 NA
GO:2000035 regulation of stem cell division NA NA 4.93e-02 NA
GO:1903294 regulation of glutamate secretion, neuro... NA NA 4.95e-02 NA
GO:0035094 response to nicotine NA NA 4.95e-02 NA
GO:0042749 regulation of circadian sleep/wake cycle NA NA 4.97e-02 NA
GO:0006897 endocytosis NA NA NA 2.41e-02
GO:0098657 import into cell NA NA NA 3.72e-02

Functional enrichments of HCPC clusters using all genes

This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0002181 cytoplasmic translation NA NA 7.84e-15 1.44e-12
GO:0006412 translation NA NA 6.33e-09 1.07e-07
GO:0001906 cell killing NA NA 3.85e-05 8.34e-03
GO:0002399 MHC class II protein complex assembly NA NA 3.85e-05 6.30e-03
GO:0002503 peptide antigen assembly with MHC class ... NA NA 3.85e-05 6.30e-03
GO:0019882 antigen processing and presentation NA NA 1.14e-04 5.62e-05
GO:0061844 antimicrobial humoral immune response me... NA NA 1.20e-04 5.51e-03
GO:0044419 biological process involved in interspec... NA NA 1.22e-04 9.42e-03
GO:0019730 antimicrobial humoral response NA NA 1.98e-04 2.34e-03
GO:0043207 response to external biotic stimulus NA NA 1.98e-04 2.34e-02
GO:0051707 response to other organism NA NA 1.98e-04 2.34e-02
GO:0048002 antigen processing and presentation of p... NA NA 3.15e-04 1.19e-04
GO:0009607 response to biotic stimulus NA NA 3.15e-04 2.72e-02
GO:0019884 antigen processing and presentation of e... NA NA 3.15e-04 1.35e-03
GO:0002504 antigen processing and presentation of p... NA NA 5.31e-04 3.04e-03
GO:0006959 humoral immune response NA NA 5.69e-04 1.14e-02
GO:0042110 T cell activation NA NA 7.42e-04 2.72e-02
GO:0002495 antigen processing and presentation of p... NA NA 8.26e-04 3.21e-03
GO:0002396 MHC protein complex assembly NA NA 8.26e-04 6.30e-03
GO:0002501 peptide antigen assembly with MHC protei... NA NA 8.26e-04 6.30e-03
GO:0002478 antigen processing and presentation of e... NA NA 9.49e-04 3.41e-03
GO:0019886 antigen processing and presentation of e... NA NA 1.59e-03 8.56e-03
GO:0019883 antigen processing and presentation of e... NA NA 2.02e-03 1.83e-02
GO:0019538 protein metabolic process NA NA 2.14e-03 NA
GO:0002250 adaptive immune response NA NA 2.14e-03 1.74e-02
GO:0006952 defense response NA NA 2.31e-03 NA
GO:0050863 regulation of T cell activation NA NA 2.31e-03 2.72e-02
GO:0046649 lymphocyte activation NA NA 2.39e-03 2.72e-02
GO:0002376 immune system process NA NA 2.39e-03 2.83e-02
GO:0043069 negative regulation of programmed cell d... NA NA 2.39e-03 6.30e-03
GO:0009605 response to external stimulus NA NA 2.60e-03 NA
GO:0097190 apoptotic signaling pathway NA NA 3.00e-03 3.15e-02
GO:0022407 regulation of cell-cell adhesion NA NA 3.04e-03 2.07e-02
GO:0043067 regulation of programmed cell death NA NA 3.04e-03 2.72e-02
GO:0019731 antibacterial humoral response NA NA 3.30e-03 4.48e-02
GO:0042127 regulation of cell population proliferat... NA NA 3.30e-03 4.48e-02
GO:0042274 ribosomal small subunit biogenesis NA NA 3.39e-03 2.72e-02
GO:0001819 positive regulation of cytokine producti... NA NA 3.39e-03 NA
GO:0006413 translational initiation NA NA 3.49e-03 2.72e-02
GO:0001913 T cell mediated cytotoxicity NA NA 3.49e-03 4.77e-02
GO:0043066 negative regulation of apoptotic process NA NA 3.49e-03 5.80e-03
GO:0006955 immune response NA NA 3.49e-03 2.83e-02
GO:0008219 cell death NA NA 3.49e-03 2.34e-02
GO:0050830 defense response to Gram-positive bacter... NA NA 3.51e-03 3.85e-02
GO:0098609 cell-cell adhesion NA NA 3.51e-03 2.07e-02
GO:1903037 regulation of leukocyte cell-cell adhesi... NA NA 3.54e-03 3.85e-02
GO:0098542 defense response to other organism NA NA 4.15e-03 NA
GO:0051249 regulation of lymphocyte activation NA NA 4.15e-03 3.96e-02
GO:0048584 positive regulation of response to stimu... NA NA 4.83e-03 NA
GO:0006334 nucleosome assembly NA NA 4.83e-03 6.95e-03
GO:0031640 killing of cells of another organism NA NA 4.83e-03 2.72e-02
GO:0141061 disruption of cell in another organism NA NA 4.83e-03 2.72e-02
GO:0002684 positive regulation of immune system pro... NA NA 4.83e-03 NA
GO:0012501 programmed cell death NA NA 5.10e-03 3.14e-02
GO:0022409 positive regulation of cell-cell adhesio... NA NA 5.10e-03 2.34e-02
GO:0050870 positive regulation of T cell activation NA NA 5.62e-03 1.74e-02
GO:0140546 defense response to symbiont NA NA 5.63e-03 NA
GO:0042981 regulation of apoptotic process NA NA 5.73e-03 3.15e-02
GO:1903039 positive regulation of leukocyte cell-ce... NA NA 5.93e-03 2.34e-02
GO:0006508 proteolysis NA NA 6.09e-03 NA
GO:0006915 apoptotic process NA NA 6.09e-03 3.14e-02
GO:2001242 regulation of intrinsic apoptotic signal... NA NA 6.09e-03 1.42e-02
GO:2001233 regulation of apoptotic signaling pathwa... NA NA 6.09e-03 NA
GO:0045321 leukocyte activation NA NA 6.36e-03 3.15e-02
GO:0032609 type II interferon production NA NA 6.36e-03 1.15e-02
GO:0032649 regulation of type II interferon product... NA NA 6.36e-03 1.15e-02
GO:0007159 leukocyte cell-cell adhesion NA NA 6.56e-03 3.44e-02
GO:0050865 regulation of cell activation NA NA 8.04e-03 NA
GO:0097529 myeloid leukocyte migration NA NA 8.08e-03 4.77e-02
GO:0008284 positive regulation of cell population p... NA NA 8.50e-03 NA
GO:0034975 protein folding in endoplasmic reticulum NA NA 9.43e-03 4.08e-02
GO:0002694 regulation of leukocyte activation NA NA 1.00e-02 NA
GO:0008283 cell population proliferation NA NA 1.02e-02 NA
GO:0051955 regulation of amino acid transport NA NA 1.03e-02 2.34e-02
GO:0090025 regulation of monocyte chemotaxis NA NA 1.06e-02 NA
GO:0009617 response to bacterium NA NA 1.06e-02 NA
GO:0065004 protein-DNA complex assembly NA NA 1.16e-02 2.31e-02
GO:0002437 inflammatory response to antigenic stimu... NA NA 1.19e-02 4.26e-02
GO:0051251 positive regulation of lymphocyte activa... NA NA 1.21e-02 3.15e-02
GO:0034087 establishment of mitotic sister chromati... NA NA 1.21e-02 NA
GO:0141060 disruption of anatomical structure in an... NA NA 1.24e-02 NA
GO:0002696 positive regulation of leukocyte activat... NA NA 1.29e-02 4.08e-02
GO:0002682 regulation of immune system process NA NA 1.32e-02 NA
GO:0050867 positive regulation of cell activation NA NA 1.33e-02 3.56e-02
GO:0071824 protein-DNA complex organization NA NA 1.33e-02 3.15e-02
GO:0050729 positive regulation of inflammatory resp... NA NA 1.39e-02 2.72e-02
GO:0034728 nucleosome organization NA NA 1.47e-02 3.56e-02
GO:0071345 cellular response to cytokine stimulus NA NA 1.54e-02 4.81e-02
GO:0001775 cell activation NA NA 1.54e-02 NA
GO:0042129 regulation of T cell proliferation NA NA 1.54e-02 NA
GO:0042254 ribosome biogenesis NA NA 1.63e-02 3.49e-02
GO:0015959 diadenosine polyphosphate metabolic proc... NA NA 1.65e-02 NA
GO:0002698 negative regulation of immune effector p... NA NA 1.76e-02 4.36e-02
GO:0031341 regulation of cell killing NA NA 1.76e-02 NA
GO:0002697 regulation of immune effector process NA NA 1.88e-02 NA
GO:0001909 leukocyte mediated cytotoxicity NA NA 1.88e-02 NA
GO:0032944 regulation of mononuclear cell prolifera... NA NA 1.93e-02 NA
GO:0002711 positive regulation of T cell mediated i... NA NA 1.93e-02 NA
GO:0030162 regulation of proteolysis NA NA 1.95e-02 NA
GO:0001916 positive regulation of T cell mediated c... NA NA 2.14e-02 NA
GO:1901652 response to peptide NA NA 2.14e-02 NA
GO:0031343 positive regulation of cell killing NA NA 2.14e-02 NA
GO:0034109 homotypic cell-cell adhesion NA NA 2.14e-02 3.15e-02
GO:0035094 response to nicotine NA NA 2.15e-02 3.15e-02
GO:0080134 regulation of response to stress NA NA 2.18e-02 NA
GO:0051246 regulation of protein metabolic process NA NA 2.18e-02 NA
GO:0002456 T cell mediated immunity NA NA 2.26e-02 NA
GO:2000767 positive regulation of cytoplasmic trans... NA NA 2.26e-02 NA
GO:0034976 response to endoplasmic reticulum stress NA NA 2.26e-02 NA
GO:0002709 regulation of T cell mediated immunity NA NA 2.26e-02 NA
GO:0070663 regulation of leukocyte proliferation NA NA 2.26e-02 NA
GO:0043331 response to dsRNA NA NA 2.30e-02 4.77e-02
GO:0002483 antigen processing and presentation of e... NA NA 2.32e-02 NA
GO:0110076 negative regulation of ferroptosis NA NA 2.35e-02 NA
GO:0031204 post-translational protein targeting to ... NA NA 2.80e-02 NA
GO:0050670 regulation of lymphocyte proliferation NA NA 2.89e-02 NA
GO:0002443 leukocyte mediated immunity NA NA 2.96e-02 NA
GO:0007056 spindle assembly involved in female meio... NA NA 2.96e-02 NA
GO:0030097 hemopoiesis NA NA 2.96e-02 NA
GO:0045087 innate immune response NA NA 3.04e-02 NA
GO:0051603 proteolysis involved in protein cataboli... NA NA 3.04e-02 NA
GO:0050778 positive regulation of immune response NA NA 3.17e-02 NA
GO:0032757 positive regulation of interleukin-8 pro... NA NA 3.18e-02 NA
GO:1902235 regulation of endoplasmic reticulum stre... NA NA 3.19e-02 NA
GO:0002449 lymphocyte mediated immunity NA NA 3.35e-02 NA
GO:0034097 response to cytokine NA NA 3.35e-02 NA
GO:0000280 nuclear division NA NA 3.39e-02 NA
GO:0050727 regulation of inflammatory response NA NA 3.44e-02 4.81e-02
GO:0050776 regulation of immune response NA NA 3.49e-02 NA
GO:0001817 regulation of cytokine production NA NA 3.72e-02 NA
GO:0016485 protein processing NA NA 3.77e-02 NA
GO:0007080 mitotic metaphase chromosome alignment NA NA 3.85e-02 NA
GO:0002252 immune effector process NA NA 3.87e-02 NA
GO:0002835 negative regulation of response to tumor... NA NA 3.89e-02 NA
GO:0002838 negative regulation of immune response t... NA NA 3.89e-02 NA
GO:0001914 regulation of T cell mediated cytotoxici... NA NA 3.92e-02 NA
GO:0140014 mitotic nuclear division NA NA 3.92e-02 4.12e-02
GO:0002683 negative regulation of immune system pro... NA NA 3.92e-02 NA
GO:0048285 organelle fission NA NA 3.93e-02 NA
GO:0043933 protein-containing complex organization NA NA 4.02e-02 2.66e-02
GO:0072599 establishment of protein localization to... NA NA 4.31e-02 NA
GO:0002474 antigen processing and presentation of p... NA NA 4.31e-02 3.15e-02
GO:0065003 protein-containing complex assembly NA NA 4.44e-02 1.04e-02
GO:0097530 granulocyte migration NA NA 4.46e-02 NA
GO:0042102 positive regulation of T cell proliferat... NA NA 4.47e-02 NA
GO:0002286 T cell activation involved in immune res... NA NA 4.53e-02 2.84e-02
GO:0001816 cytokine production NA NA 4.62e-02 NA
GO:0032689 negative regulation of type II interfero... NA NA 4.62e-02 2.72e-02
GO:0050777 negative regulation of immune response NA NA 4.69e-02 NA
GO:0030163 protein catabolic process NA NA 4.69e-02 NA
GO:0010628 positive regulation of gene expression NA NA 4.69e-02 NA
GO:0097193 intrinsic apoptotic signaling pathway NA NA 4.69e-02 NA
GO:0072677 eosinophil migration NA NA 4.69e-02 3.85e-02
GO:2001234 negative regulation of apoptotic signali... NA NA 4.82e-02 NA
GO:0031099 regeneration NA NA 4.86e-02 2.72e-02
GO:1902253 regulation of intrinsic apoptotic signal... NA NA 4.86e-02 NA
GO:0045839 negative regulation of mitotic nuclear d... NA NA 4.89e-02 NA
GO:0048522 positive regulation of cellular process NA NA 4.89e-02 NA
GO:0045047 protein targeting to ER NA NA 4.89e-02 NA
GO:0006119 oxidative phosphorylation NA NA NA 7.21e-03
GO:0000070 mitotic sister chromatid segregation NA NA NA 2.14e-02
GO:0089718 amino acid import across plasma membrane NA NA NA 2.31e-02
GO:0000819 sister chromatid segregation NA NA NA 2.72e-02
GO:0042773 ATP synthesis coupled electron transport NA NA NA 2.72e-02
GO:0042775 mitochondrial ATP synthesis coupled elec... NA NA NA 2.72e-02
GO:0022613 ribonucleoprotein complex biogenesis NA NA NA 2.83e-02
GO:0032890 regulation of organic acid transport NA NA NA 3.15e-02
GO:1902622 regulation of neutrophil migration NA NA NA 4.08e-02
GO:1902624 positive regulation of neutrophil migrat... NA NA NA 4.36e-02
GO:0048524 positive regulation of viral process NA NA NA 4.77e-02
GO:0035265 organ growth NA NA NA 4.81e-02
GO:0015800 acidic amino acid transport NA NA NA 4.88e-02

Functional enrichments of PCs using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0050776 regulation of immune response 1.29e-02 NA NA NA
GO:0050778 positive regulation of immune response 1.29e-02 NA NA NA
GO:0006508 proteolysis 3.04e-02 NA NA NA
GO:0006955 immune response 3.04e-02 NA NA NA
GO:0016043 cellular component organization 3.04e-02 NA NA NA
GO:0071840 cellular component organization or bioge... 3.04e-02 NA NA NA
GO:0022607 cellular component assembly 3.04e-02 NA NA NA
GO:0044085 cellular component biogenesis 3.04e-02 NA NA NA
GO:0043933 protein-containing complex organization 3.04e-02 NA NA NA
GO:0065003 protein-containing complex assembly 3.04e-02 NA NA NA
GO:0009891 positive regulation of biosynthetic proc... 3.04e-02 NA NA NA
GO:0010557 positive regulation of macromolecule bio... 3.04e-02 NA NA NA
GO:0010604 positive regulation of macromolecule met... 3.04e-02 NA NA NA
GO:0031325 positive regulation of cellular metaboli... 3.04e-02 NA NA NA
GO:0031328 positive regulation of cellular biosynth... 3.04e-02 NA NA NA
GO:0048584 positive regulation of response to stimu... 3.64e-02 NA NA NA
GO:0006950 response to stress 3.66e-02 NA NA NA
GO:0009893 positive regulation of metabolic process 3.66e-02 NA NA NA
GO:0007267 cell-cell signaling 3.90e-02 NA NA NA
GO:0001775 cell activation 3.90e-02 NA NA NA
GO:0045321 leukocyte activation 3.90e-02 NA NA NA
GO:0051128 regulation of cellular component organiz... 3.90e-02 NA NA NA
GO:0002682 regulation of immune system process 4.13e-02 NA NA NA
GO:0002684 positive regulation of immune system pro... 4.13e-02 NA NA NA
GO:0030154 cell differentiation 4.93e-02 NA NA NA
GO:0048869 cellular developmental process 4.93e-02 NA NA NA
GO:0048518 positive regulation of biological proces... 4.93e-02 NA NA NA
GO:0050789 regulation of biological process NA 2.33e-02 NA NA
GO:0065007 biological regulation NA 2.33e-02 NA NA
GO:0050794 regulation of cellular process NA 2.33e-02 NA NA
GO:0009987 cellular process NA 3.54e-02 NA NA

Functional enrichments of HCPC clusters using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0006508 proteolysis NA 4.4e-02 NA NA
GO:0019538 protein metabolic process NA 4.7e-02 NA NA

CC - Enrichments for Principal Components

Functional enrichments of PCs using all genes


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0070062 extracellular exosome 5.39e-32 NA NA NA
GO:1903561 extracellular vesicle 5.39e-32 NA NA NA
GO:0043230 extracellular organelle 5.39e-32 NA NA NA
GO:0065010 extracellular membrane-bounded organelle 5.39e-32 NA NA NA
GO:0044391 ribosomal subunit 1.04e-28 NA 1.78e-02 NA
GO:0022625 cytosolic large ribosomal subunit 2.80e-27 NA 1.73e-05 NA
GO:0005615 extracellular space 3.55e-27 NA NA NA
GO:0005576 extracellular region 1.99e-25 NA NA NA
GO:0031982 vesicle 2.50e-22 NA NA NA
GO:0022626 cytosolic ribosome 1.05e-21 NA 2.78e-07 NA
GO:0005840 ribosome 9.28e-21 NA 1.88e-03 NA
GO:0015934 large ribosomal subunit 1.63e-20 NA 4.69e-02 NA
GO:0031090 organelle membrane 5.62e-14 NA NA NA
GO:0005783 endoplasmic reticulum 1.20e-13 NA NA NA
GO:0098796 membrane protein complex 4.62e-12 NA NA NA
GO:0030141 secretory granule 1.02e-11 NA NA NA
GO:0012505 endomembrane system 1.26e-11 NA NA NA
GO:0022627 cytosolic small ribosomal subunit 3.61e-11 NA NA NA
GO:0099503 secretory vesicle 8.39e-11 NA NA NA
GO:0098588 bounding membrane of organelle 1.33e-10 NA NA NA
GO:0000323 lytic vacuole 3.00e-10 NA NA NA
GO:0005764 lysosome 3.00e-10 NA NA NA
GO:0015935 small ribosomal subunit 1.64e-09 NA NA NA
GO:0031410 cytoplasmic vesicle 4.75e-09 NA NA NA
GO:0097708 intracellular vesicle 8.60e-09 NA NA NA
GO:0016020 membrane 9.51e-09 NA NA NA
GO:0005773 vacuole 2.17e-08 NA NA NA
GO:0005789 endoplasmic reticulum membrane 2.17e-08 NA NA NA
GO:0042175 nuclear outer membrane-endoplasmic retic... 2.65e-08 NA NA NA
GO:0098827 endoplasmic reticulum subcompartment 3.11e-08 NA NA NA
GO:0031984 organelle subcompartment 5.16e-08 NA NA NA
GO:0035577 azurophil granule membrane 5.16e-08 NA NA NA
GO:1990904 ribonucleoprotein complex 1.44e-07 NA 1.88e-03 NA
GO:0005766 primary lysosome 2.23e-07 NA NA NA
GO:0042582 azurophil granule 2.23e-07 NA NA NA
GO:0030659 cytoplasmic vesicle membrane 3.84e-07 NA NA NA
GO:0000139 Golgi membrane 3.84e-07 NA NA NA
GO:0005740 mitochondrial envelope 5.15e-07 NA NA NA
GO:0030667 secretory granule membrane 7.11e-07 NA NA NA
GO:0005774 vacuolar membrane 9.39e-07 NA NA NA
GO:0031966 mitochondrial membrane 9.39e-07 NA NA NA
GO:0012506 vesicle membrane 9.43e-07 NA NA NA
GO:0005765 lysosomal membrane 1.01e-06 NA NA NA
GO:0098852 lytic vacuole membrane 1.01e-06 NA NA NA
GO:0042611 MHC protein complex 1.03e-06 NA 9.35e-06 NA
GO:0098803 respiratory chain complex 1.18e-06 NA NA NA
GO:0019866 organelle inner membrane 1.37e-06 NA NA NA
GO:0030133 transport vesicle 1.87e-06 NA NA NA
GO:0005925 focal adhesion 2.17e-06 NA NA NA
GO:0030055 cell-substrate junction 2.17e-06 NA NA NA
GO:0005743 mitochondrial inner membrane 3.01e-06 NA NA NA
GO:0009986 cell surface 3.01e-06 NA NA NA
GO:0030135 coated vesicle 4.22e-06 NA NA NA
GO:0030662 coated vesicle membrane 5.74e-06 NA NA NA
GO:0098552 side of membrane 1.01e-05 NA NA NA
GO:0042613 MHC class II protein complex 1.01e-05 NA 8.02e-06 NA
GO:0042470 melanosome 1.04e-05 NA NA NA
GO:0048770 pigment granule 1.04e-05 NA NA NA
GO:0098798 mitochondrial protein-containing complex 1.21e-05 NA NA NA
GO:0016469 proton-transporting two-sector ATPase co... 2.22e-05 NA NA NA
GO:0005839 proteasome core complex 2.28e-05 NA NA NA
GO:0101002 ficolin-1-rich granule 5.75e-05 NA NA NA
GO:0031983 vesicle lumen 6.19e-05 NA NA NA
GO:0060205 cytoplasmic vesicle lumen 6.19e-05 NA NA NA
GO:0034774 secretory granule lumen 7.73e-05 NA NA NA
GO:1990351 transporter complex 1.67e-04 NA NA NA
GO:0090533 cation-transporting ATPase complex 2.14e-04 NA NA NA
GO:0000315 organellar large ribosomal subunit 2.15e-04 NA NA NA
GO:0005762 mitochondrial large ribosomal subunit 2.15e-04 NA NA NA
GO:0070820 tertiary granule 2.37e-04 NA NA NA
GO:0009897 external side of plasma membrane 2.52e-04 NA NA NA
GO:0031967 organelle envelope 2.57e-04 NA NA NA
GO:0031902 late endosome membrane 2.62e-04 NA NA NA
GO:0005739 mitochondrion 2.92e-04 NA NA NA
GO:1904813 ficolin-1-rich granule lumen 2.93e-04 NA NA NA
GO:0005775 vacuolar lumen 3.47e-04 NA NA NA
GO:0010008 endosome membrane 3.55e-04 NA NA NA
GO:0030665 clathrin-coated vesicle membrane 4.44e-04 NA NA NA
GO:0098857 membrane microdomain 4.67e-04 NA NA NA
GO:0005737 cytoplasm 4.67e-04 NA NA NA
GO:0045335 phagocytic vesicle 5.50e-04 NA NA NA
GO:0000313 organellar ribosome 5.50e-04 NA NA NA
GO:0005761 mitochondrial ribosome 5.50e-04 NA NA NA
GO:0033178 proton-transporting two-sector ATPase co... 5.52e-04 NA NA NA
GO:0005794 Golgi apparatus 5.97e-04 NA NA NA
GO:1902495 transmembrane transporter complex 7.04e-04 NA NA NA
GO:0030666 endocytic vesicle membrane 7.81e-04 NA NA NA
GO:0030134 COPII-coated ER to Golgi transport vesic... 8.70e-04 NA 4.58e-02 NA
GO:0045121 membrane raft 8.85e-04 NA NA NA
GO:0034361 very-low-density lipoprotein particle 1.46e-03 NA NA NA
GO:0034385 triglyceride-rich plasma lipoprotein par... 1.46e-03 NA NA NA
GO:0030669 clathrin-coated endocytic vesicle membra... 1.60e-03 NA NA NA
GO:0043227 membrane-bounded organelle 1.63e-03 NA NA NA
GO:0000502 proteasome complex 1.77e-03 NA NA NA
GO:0005791 rough endoplasmic reticulum 2.18e-03 NA NA NA
GO:1905369 endopeptidase complex 2.61e-03 NA NA NA
GO:0005770 late endosome 2.61e-03 NA NA NA
GO:0045259 proton-transporting ATP synthase complex 2.73e-03 NA NA NA
GO:0030670 phagocytic vesicle membrane 2.98e-03 NA NA NA
GO:0019774 proteasome core complex, beta-subunit co... 3.31e-03 NA 4.45e-02 NA
GO:0030136 clathrin-coated vesicle 3.43e-03 NA NA NA
GO:0000221 vacuolar proton-transporting V-type ATPa... 3.43e-03 NA NA NA
GO:0033180 proton-transporting V-type ATPase, V1 do... 3.43e-03 NA NA NA
GO:0098553 lumenal side of endoplasmic reticulum me... 3.44e-03 NA 4.50e-03 NA
GO:0031588 nucleotide-activated protein kinase comp... 3.60e-03 NA NA NA
GO:0033176 proton-transporting V-type ATPase comple... 3.60e-03 NA NA NA
GO:0045334 clathrin-coated endocytic vesicle 4.01e-03 NA NA NA
GO:0033116 endoplasmic reticulum-Golgi intermediate... 4.30e-03 NA NA NA
GO:1904724 tertiary granule lumen 4.50e-03 NA NA NA
GO:0140534 endoplasmic reticulum protein-containing... 4.76e-03 NA 1.03e-03 NA
GO:0030663 COPI-coated vesicle membrane 4.86e-03 NA 1.78e-02 NA
GO:0005787 signal peptidase complex 4.86e-03 NA NA NA
GO:0045277 respiratory chain complex IV 5.09e-03 NA NA NA
GO:0043231 intracellular membrane-bounded organelle 5.30e-03 NA NA NA
GO:0030139 endocytic vesicle 5.36e-03 NA NA NA
GO:0008290 F-actin capping protein complex 5.36e-03 NA NA NA
GO:0098797 plasma membrane protein complex 5.42e-03 NA NA NA
GO:0005793 endoplasmic reticulum-Golgi intermediate... 5.65e-03 NA NA NA
GO:0030137 COPI-coated vesicle 5.86e-03 NA 3.18e-02 NA
GO:0005788 endoplasmic reticulum lumen 6.08e-03 NA NA NA
GO:0072562 blood microparticle 6.37e-03 NA NA NA
GO:0030054 cell junction 7.23e-03 NA NA NA
GO:0097197 tetraspanin-enriched microdomain 7.40e-03 NA NA NA
GO:0005798 Golgi-associated vesicle 7.86e-03 NA NA NA
GO:0031970 organelle envelope lumen 8.68e-03 NA NA NA
GO:0062023 collagen-containing extracellular matrix 9.41e-03 NA NA NA
GO:0005768 endosome 9.61e-03 NA NA 3.38e-03
GO:0012507 ER to Golgi transport vesicle membrane 9.78e-03 NA 1.80e-02 NA
GO:0001772 immunological synapse 1.08e-02 NA NA NA
GO:0045202 synapse 1.09e-02 NA NA NA
GO:0016471 vacuolar proton-transporting V-type ATPa... 1.14e-02 NA NA NA
GO:0042581 specific granule 1.28e-02 NA NA NA
GO:0042612 MHC class I protein complex 1.30e-02 NA NA NA
GO:0098533 ATPase dependent transmembrane transport... 1.37e-02 NA NA NA
GO:0030658 transport vesicle membrane 1.37e-02 NA NA NA
GO:0005758 mitochondrial intermembrane space 1.37e-02 NA NA NA
GO:0070765 gamma-secretase complex 1.64e-02 NA NA NA
GO:0071944 cell periphery 1.83e-02 NA NA NA
GO:0005834 heterotrimeric G-protein complex 1.86e-02 NA 3.92e-02 NA
GO:0035578 azurophil granule lumen 1.86e-02 NA NA NA
GO:0019773 proteasome core complex, alpha-subunit c... 2.19e-02 NA NA NA
GO:0031904 endosome lumen 2.19e-02 NA NA NA
GO:0005886 plasma membrane 2.28e-02 NA NA NA
GO:0030312 external encapsulating structure 2.61e-02 NA NA NA
GO:0031012 extracellular matrix 2.61e-02 NA NA NA
GO:0140596 TOM complex 2.73e-02 NA NA NA
GO:0070161 anchoring junction 3.01e-02 NA NA NA
GO:0070937 CRD-mediated mRNA stability complex 3.04e-02 NA NA NA
GO:0043202 lysosomal lumen 3.12e-02 NA NA NA
GO:0044233 mitochondria-associated endoplasmic reti... 3.23e-02 NA NA NA
GO:0098556 cytoplasmic side of rough endoplasmic re... 3.41e-02 NA NA NA
GO:0071159 NF-kappaB complex 3.51e-02 NA NA NA
GO:0098576 lumenal side of membrane 3.53e-02 NA 1.81e-02 NA
GO:0030867 rough endoplasmic reticulum membrane 4.22e-02 NA NA NA
GO:0008021 synaptic vesicle 4.22e-02 NA NA NA
GO:0070069 cytochrome complex 4.69e-02 NA NA NA
GO:0032040 small-subunit processome 4.79e-02 NA 4.58e-02 NA
GO:0044322 endoplasmic reticulum quality control co... 4.84e-02 NA NA NA
GO:0019897 extrinsic component of plasma membrane 4.84e-02 NA NA NA
GO:0032991 protein-containing complex 4.92e-02 NA 4.84e-06 NA
GO:0005694 chromosome NA 4.22e-08 7.88e-20 NA
GO:0043228 non-membrane-bounded organelle NA 5.08e-07 1.30e-12 NA
GO:0043232 intracellular non-membrane-bounded organ... NA 5.08e-07 1.30e-12 NA
GO:0005856 cytoskeleton NA 5.08e-07 1.89e-02 NA
GO:0005815 microtubule organizing center NA 3.19e-06 NA NA
GO:0015630 microtubule cytoskeleton NA 4.65e-06 1.45e-02 NA
GO:0005814 centriole NA 2.14e-05 NA NA
GO:0036064 ciliary basal body NA 5.61e-05 NA NA
GO:0005654 nucleoplasm NA 1.94e-04 1.79e-07 NA
GO:0140513 nuclear protein-containing complex NA 3.85e-04 2.97e-03 NA
GO:0000228 nuclear chromosome NA 5.15e-04 7.45e-04 NA
GO:0031981 nuclear lumen NA 8.40e-04 2.88e-09 NA
GO:0005657 replication fork NA 1.35e-03 NA NA
GO:0005813 centrosome NA 1.43e-03 NA NA
GO:0000785 chromatin NA 3.04e-03 1.95e-11 NA
GO:0005634 nucleus NA 5.27e-03 1.48e-07 NA
GO:0031390 Ctf18 RFC-like complex NA 9.21e-03 NA NA
GO:0071162 CMG complex NA 1.06e-02 NA NA
GO:0031261 DNA replication preinitiation complex NA 1.10e-02 2.75e-02 NA
GO:0016607 nuclear speck NA 1.17e-02 NA NA
GO:0005658 alpha DNA polymerase:primase complex NA 1.51e-02 NA NA
GO:0016604 nuclear body NA 1.51e-02 NA NA
GO:0034451 centriolar satellite NA 1.60e-02 NA NA
GO:0099738 cell cortex region NA 1.61e-02 NA NA
GO:0005663 DNA replication factor C complex NA 2.47e-02 NA NA
GO:0035097 histone methyltransferase complex NA 2.59e-02 NA NA
GO:0098687 chromosomal region NA NA 6.35e-14 NA
GO:0000775 chromosome, centromeric region NA NA 7.97e-14 NA
GO:0000786 nucleosome NA NA 7.71e-12 NA
GO:0032993 protein-DNA complex NA NA 7.70e-11 NA
GO:0000793 condensed chromosome NA NA 1.73e-10 NA
GO:0000779 condensed chromosome, centromeric region NA NA 4.82e-08 NA
GO:0000776 kinetochore NA NA 5.57e-08 NA
GO:0034399 nuclear periphery NA NA 2.91e-05 NA
GO:0000940 outer kinetochore NA NA 9.77e-05 NA
GO:0005730 nucleolus NA NA 3.02e-04 NA
GO:0034663 endoplasmic reticulum chaperone complex NA NA 3.57e-04 NA
GO:0005819 spindle NA NA 4.12e-04 NA
GO:0016363 nuclear matrix NA NA 6.18e-04 NA
GO:0099080 supramolecular complex NA NA 6.18e-04 NA
GO:0034506 chromosome, centromeric core domain NA NA 6.18e-04 NA
GO:0031974 membrane-enclosed lumen NA NA 6.90e-04 NA
GO:0043233 organelle lumen NA NA 6.90e-04 NA
GO:0070013 intracellular organelle lumen NA NA 6.90e-04 NA
GO:0045120 pronucleus NA NA 7.91e-04 NA
GO:0000803 sex chromosome NA NA 1.18e-03 NA
GO:0043505 CENP-A containing nucleosome NA NA 1.46e-03 NA
GO:0061638 CENP-A containing chromatin NA NA 1.46e-03 NA
GO:0070603 SWI/SNF superfamily-type complex NA NA 1.89e-03 NA
GO:0010369 chromocenter NA NA 2.40e-03 NA
GO:0001674 female germ cell nucleus NA NA 4.50e-03 NA
GO:0001940 male pronucleus NA NA 4.50e-03 NA
GO:0000781 chromosome, telomeric region NA NA 4.91e-03 NA
GO:0001939 female pronucleus NA NA 5.56e-03 NA
GO:0000922 spindle pole NA NA 6.57e-03 NA
GO:0001741 XY body NA NA 7.54e-03 NA
GO:0051233 spindle midzone NA NA 8.65e-03 NA
GO:0032133 chromosome passenger complex NA NA 9.61e-03 NA
GO:0072686 mitotic spindle NA NA 1.32e-02 NA
GO:0005871 kinesin complex NA NA 1.45e-02 NA
GO:0008250 oligosaccharyltransferase complex NA NA 1.48e-02 NA
GO:0016514 SWI/SNF complex NA NA 1.54e-02 NA
GO:0000939 inner kinetochore NA NA 1.57e-02 NA
GO:0035060 brahma complex NA NA 1.62e-02 NA
GO:0005881 cytoplasmic microtubule NA NA 1.62e-02 NA
GO:0000796 condensin complex NA NA 1.66e-02 NA
GO:1904949 ATPase complex NA NA 1.78e-02 NA
GO:1902494 catalytic complex NA NA 1.80e-02 NA
GO:0000794 condensed nuclear chromosome NA NA 1.81e-02 NA
GO:0005874 microtubule NA NA 2.21e-02 NA
GO:0071014 post-mRNA release spliceosomal complex NA NA 2.27e-02 NA
GO:0097165 nuclear stress granule NA NA 2.36e-02 NA
GO:0031234 extrinsic component of cytoplasmic side ... NA NA 2.43e-02 NA
GO:0005652 nuclear lamina NA NA 3.18e-02 NA
GO:0140288 GBAF complex NA NA 3.35e-02 NA
GO:0097431 mitotic spindle pole NA NA 3.81e-02 NA
GO:1990023 mitotic spindle midzone NA NA 3.92e-02 NA
GO:0035861 site of double-strand break NA NA 3.92e-02 NA
GO:0000930 gamma-tubulin complex NA NA 3.92e-02 NA
GO:0000792 heterochromatin NA NA 3.92e-02 NA
GO:0099513 polymeric cytoskeletal fiber NA NA 4.33e-02 NA
GO:0005681 spliceosomal complex NA NA 4.34e-02 NA
GO:0005784 Sec61 translocon complex NA NA 4.58e-02 NA
GO:0071256 translocon complex NA NA 4.58e-02 NA
GO:0001740 Barr body NA NA 4.58e-02 NA
GO:0071013 catalytic step 2 spliceosome NA NA 4.91e-02 NA

Functional enrichments of HCPC clusters using all genes

This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0070062 extracellular exosome NA NA 1.95e-20 3.63e-16
GO:1903561 extracellular vesicle NA NA 1.95e-20 3.63e-16
GO:0043230 extracellular organelle NA NA 1.95e-20 3.64e-16
GO:0065010 extracellular membrane-bounded organelle NA NA 1.95e-20 3.64e-16
GO:0022626 cytosolic ribosome NA NA 4.53e-19 2.89e-15
GO:0005615 extracellular space NA NA 6.82e-19 1.39e-13
GO:0022625 cytosolic large ribosomal subunit NA NA 2.72e-18 3.53e-12
GO:0044391 ribosomal subunit NA NA 1.02e-16 4.23e-14
GO:0005576 extracellular region NA NA 2.17e-16 1.04e-11
GO:0005840 ribosome NA NA 2.17e-16 4.78e-13
GO:0015934 large ribosomal subunit NA NA 9.33e-13 2.23e-08
GO:0042611 MHC protein complex NA NA 2.97e-10 7.83e-06
GO:0031982 vesicle NA NA 2.95e-09 1.44e-08
GO:1990904 ribonucleoprotein complex NA NA 7.87e-09 4.08e-07
GO:0005783 endoplasmic reticulum NA NA 4.54e-08 2.49e-07
GO:0005839 proteasome core complex NA NA 2.17e-07 3.14e-04
GO:0042613 MHC class II protein complex NA NA 3.45e-07 1.50e-04
GO:0000786 nucleosome NA NA 3.66e-07 1.44e-06
GO:0000139 Golgi membrane NA NA 3.06e-06 1.50e-04
GO:0000775 chromosome, centromeric region NA NA 4.39e-06 4.87e-05
GO:0005789 endoplasmic reticulum membrane NA NA 4.54e-06 3.24e-06
GO:0098827 endoplasmic reticulum subcompartment NA NA 4.79e-06 3.67e-06
GO:0140534 endoplasmic reticulum protein-containing... NA NA 4.79e-06 1.08e-03
GO:0022627 cytosolic small ribosomal subunit NA NA 5.08e-06 1.11e-06
GO:0032991 protein-containing complex NA NA 1.28e-05 5.46e-06
GO:0042175 nuclear outer membrane-endoplasmic retic... NA NA 1.28e-05 5.46e-06
GO:0005925 focal adhesion NA NA 1.74e-05 7.48e-03
GO:0030055 cell-substrate junction NA NA 1.74e-05 7.48e-03
GO:0030663 COPI-coated vesicle membrane NA NA 2.08e-05 1.08e-03
GO:0098796 membrane protein complex NA NA 2.64e-05 4.87e-05
GO:0030133 transport vesicle NA NA 3.29e-05 8.31e-06
GO:0015935 small ribosomal subunit NA NA 8.81e-05 5.75e-06
GO:0031984 organelle subcompartment NA NA 2.03e-04 1.56e-04
GO:0000221 vacuolar proton-transporting V-type ATPa... NA NA 3.09e-04 1.56e-02
GO:0033180 proton-transporting V-type ATPase, V1 do... NA NA 3.09e-04 1.56e-02
GO:0019774 proteasome core complex, beta-subunit co... NA NA 4.30e-04 9.66e-03
GO:0030662 coated vesicle membrane NA NA 9.02e-04 1.71e-03
GO:0098553 lumenal side of endoplasmic reticulum me... NA NA 1.07e-03 2.00e-04
GO:0042612 MHC class I protein complex NA NA 1.07e-03 NA
GO:0098552 side of membrane NA NA 1.07e-03 1.35e-02
GO:0042470 melanosome NA NA 1.07e-03 2.89e-04
GO:0048770 pigment granule NA NA 1.07e-03 2.89e-04
GO:0012505 endomembrane system NA NA 1.15e-03 4.10e-03
GO:0031234 extrinsic component of cytoplasmic side ... NA NA 1.15e-03 1.82e-03
GO:0098687 chromosomal region NA NA 1.19e-03 1.94e-02
GO:0016020 membrane NA NA 1.28e-03 7.48e-03
GO:0032993 protein-DNA complex NA NA 1.31e-03 1.91e-03
GO:0005834 heterotrimeric G-protein complex NA NA 1.57e-03 1.43e-03
GO:0033178 proton-transporting two-sector ATPase co... NA NA 1.57e-03 NA
GO:0000323 lytic vacuole NA NA 1.57e-03 2.29e-03
GO:0005764 lysosome NA NA 1.57e-03 2.29e-03
GO:0000776 kinetochore NA NA 1.62e-03 1.19e-02
GO:0030137 COPI-coated vesicle NA NA 1.63e-03 7.97e-04
GO:0000793 condensed chromosome NA NA 1.86e-03 1.94e-02
GO:0030135 coated vesicle NA NA 1.89e-03 1.12e-02
GO:0005737 cytoplasm NA NA 2.05e-03 NA
GO:0030126 COPI vesicle coat NA NA 2.10e-03 2.21e-02
GO:0030141 secretory granule NA NA 2.11e-03 1.58e-03
GO:0000779 condensed chromosome, centromeric region NA NA 2.11e-03 1.67e-02
GO:0005784 Sec61 translocon complex NA NA 2.31e-03 NA
GO:0071256 translocon complex NA NA 2.31e-03 NA
GO:0005766 primary lysosome NA NA 2.79e-03 2.89e-04
GO:0042582 azurophil granule NA NA 2.79e-03 2.89e-04
GO:0031090 organelle membrane NA NA 2.79e-03 1.62e-02
GO:0030134 COPII-coated ER to Golgi transport vesic... NA NA 2.91e-03 3.14e-05
GO:0012507 ER to Golgi transport vesicle membrane NA NA 3.43e-03 5.36e-04
GO:0099503 secretory vesicle NA NA 3.43e-03 1.17e-03
GO:0032040 small-subunit processome NA NA 4.98e-03 9.71e-03
GO:0019773 proteasome core complex, alpha-subunit c... NA NA 4.98e-03 NA
GO:0005773 vacuole NA NA 5.21e-03 1.37e-02
GO:0030892 mitotic cohesin complex NA NA 6.60e-03 NA
GO:0098576 lumenal side of membrane NA NA 7.46e-03 1.91e-03
GO:1904724 tertiary granule lumen NA NA 8.40e-03 4.38e-02
GO:0043231 intracellular membrane-bounded organelle NA NA 8.50e-03 1.35e-02
GO:0019897 extrinsic component of plasma membrane NA NA 8.50e-03 1.85e-02
GO:0031902 late endosome membrane NA NA 8.85e-03 NA
GO:0043227 membrane-bounded organelle NA NA 1.00e-02 1.94e-02
GO:0009986 cell surface NA NA 1.08e-02 NA
GO:1905360 GTPase complex NA NA 1.11e-02 1.60e-02
GO:0098797 plasma membrane protein complex NA NA 1.11e-02 4.16e-02
GO:0005787 signal peptidase complex NA NA 1.12e-02 NA
GO:0030658 transport vesicle membrane NA NA 1.35e-02 4.37e-03
GO:0001940 male pronucleus NA NA 1.36e-02 NA
GO:0000502 proteasome complex NA NA 1.39e-02 3.02e-02
GO:0035577 azurophil granule membrane NA NA 1.47e-02 6.29e-03
GO:0008250 oligosaccharyltransferase complex NA NA 1.47e-02 NA
GO:0098588 bounding membrane of organelle NA NA 1.53e-02 NA
GO:0008278 cohesin complex NA NA 1.58e-02 NA
GO:0005791 rough endoplasmic reticulum NA NA 1.58e-02 7.95e-03
GO:0051233 spindle midzone NA NA 1.59e-02 1.94e-02
GO:0000940 outer kinetochore NA NA 1.65e-02 NA
GO:0030669 clathrin-coated endocytic vesicle membra... NA NA 1.67e-02 2.83e-02
GO:1905369 endopeptidase complex NA NA 1.86e-02 4.01e-02
GO:0070161 anchoring junction NA NA 1.91e-02 NA
GO:1902494 catalytic complex NA NA 2.39e-02 NA
GO:0034663 endoplasmic reticulum chaperone complex NA NA 2.42e-02 1.21e-02
GO:0030289 protein phosphatase 4 complex NA NA 2.52e-02 NA
GO:0045277 respiratory chain complex IV NA NA 2.62e-02 NA
GO:0005794 Golgi apparatus NA NA 2.71e-02 NA
GO:0005730 nucleolus NA NA 2.78e-02 NA
GO:0098798 mitochondrial protein-containing complex NA NA 2.85e-02 NA
GO:0030684 preribosome NA NA 3.23e-02 4.12e-02
GO:0009897 external side of plasma membrane NA NA 3.29e-02 NA
GO:0005798 Golgi-associated vesicle NA NA 3.64e-02 NA
GO:0016469 proton-transporting two-sector ATPase co... NA NA 3.83e-02 NA
GO:0034774 secretory granule lumen NA NA 4.63e-02 3.20e-02
GO:0071007 U2-type catalytic step 2 spliceosome NA NA 4.73e-02 1.94e-02
GO:0030054 cell junction NA NA 5.00e-02 NA
GO:0005775 vacuolar lumen NA NA 5.00e-02 1.31e-02
GO:0098803 respiratory chain complex NA NA NA 2.59e-03
GO:0005793 endoplasmic reticulum-Golgi intermediate... NA NA NA 1.97e-02
GO:0034506 chromosome, centromeric core domain NA NA NA 2.30e-02
GO:0033116 endoplasmic reticulum-Golgi intermediate... NA NA NA 2.35e-02
GO:0008541 proteasome regulatory particle, lid subc... NA NA NA 3.02e-02
GO:0031983 vesicle lumen NA NA NA 4.10e-02
GO:0060205 cytoplasmic vesicle lumen NA NA NA 4.10e-02
GO:0035578 azurophil granule lumen NA NA NA 4.38e-02
GO:0043505 CENP-A containing nucleosome NA NA NA 4.46e-02
GO:0061638 CENP-A containing chromatin NA NA NA 4.46e-02
GO:0030496 midbody NA NA NA 4.63e-02
GO:0030867 rough endoplasmic reticulum membrane NA NA NA 4.95e-02

Functional enrichments of PCs using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0005768 endosome 7.24e-03 NA NA NA
GO:0005783 endoplasmic reticulum 1.17e-02 NA NA NA
GO:0005615 extracellular space 1.17e-02 NA NA NA
GO:0043230 extracellular organelle 1.17e-02 NA NA NA
GO:0065010 extracellular membrane-bounded organelle 1.17e-02 NA NA NA
GO:0070062 extracellular exosome 1.17e-02 NA NA NA
GO:1903561 extracellular vesicle 1.17e-02 NA NA NA
GO:0016020 membrane 2.39e-02 NA NA NA
GO:0071944 cell periphery 2.82e-02 NA NA NA
GO:0005886 plasma membrane 3.44e-02 NA NA NA

Functional enrichments of HCPC clusters using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0071944 cell periphery NA NA NA 4.03e-02
GO:0016020 membrane NA NA NA 4.03e-02
GO:0005886 plasma membrane NA NA NA 4.84e-02

MF - Enrichments for Principal Components

Functional enrichments of PCs using all genes


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0003735 structural constituent of ribosome 1.59e-27 NA NA NA
GO:0023026 MHC class II protein complex binding 2.66e-08 NA NA NA
GO:0003924 GTPase activity 1.50e-06 NA NA NA
GO:0005198 structural molecule activity 1.68e-06 NA 6.01e-04 NA
GO:0023023 MHC protein complex binding 1.92e-06 NA NA NA
GO:0140678 molecular function inhibitor activity 4.78e-05 NA NA NA
GO:0008430 selenium binding 1.86e-04 NA NA NA
GO:0019001 guanyl nucleotide binding 1.86e-04 NA NA NA
GO:0032561 guanyl ribonucleotide binding 1.86e-04 NA NA NA
GO:0042287 MHC protein binding 1.87e-04 NA NA NA
GO:0005525 GTP binding 2.02e-04 NA NA NA
GO:0016209 antioxidant activity 2.59e-04 NA NA NA
GO:0003925 G protein activity 2.59e-04 NA NA NA
GO:0032395 MHC class II receptor activity 2.59e-04 NA 6.95e-06 NA
GO:0019003 GDP binding 2.59e-04 NA NA NA
GO:0019843 rRNA binding 2.59e-04 NA NA NA
GO:0015078 proton transmembrane transporter activit... 4.11e-04 NA NA NA
GO:0140375 immune receptor activity 4.30e-04 NA NA NA
GO:0051920 peroxiredoxin activity 5.38e-04 NA NA NA
GO:0004857 enzyme inhibitor activity 6.56e-04 NA NA NA
GO:0042277 peptide binding 9.15e-04 NA NA NA
GO:0031386 protein tag activity 9.15e-04 NA NA NA
GO:0141047 molecular tag activity 9.15e-04 NA NA NA
GO:0004866 endopeptidase inhibitor activity 9.15e-04 NA NA NA
GO:0031681 G-protein beta-subunit binding 9.31e-04 NA NA NA
GO:0009055 electron transfer activity 9.58e-04 NA NA NA
GO:0003823 antigen binding 1.15e-03 NA 3.04e-02 NA
GO:0061134 peptidase regulator activity 1.87e-03 NA NA NA
GO:0005102 signaling receptor binding 2.28e-03 NA NA NA
GO:0016668 oxidoreductase activity, acting on a sul... 2.29e-03 NA NA NA
GO:0030414 peptidase inhibitor activity 2.40e-03 NA NA NA
GO:0097177 mitochondrial ribosome binding 3.66e-03 NA NA NA
GO:0042605 peptide antigen binding 3.76e-03 NA 7.37e-03 NA
GO:0015453 oxidoreduction-driven active transmembra... 3.81e-03 NA NA NA
GO:0048027 mRNA 5'-UTR binding 5.16e-03 NA NA NA
GO:0004601 peroxidase activity 5.58e-03 NA NA NA
GO:0019763 immunoglobulin receptor activity 5.58e-03 NA NA NA
GO:0016684 oxidoreductase activity, acting on perox... 8.77e-03 NA NA NA
GO:0003743 translation initiation factor activity 8.77e-03 NA NA NA
GO:0008379 thioredoxin peroxidase activity 8.77e-03 NA NA NA
GO:0140824 thioredoxin-dependent peroxiredoxin acti... 8.77e-03 NA NA NA
GO:0045296 cadherin binding 1.02e-02 NA NA NA
GO:0015180 L-alanine transmembrane transporter acti... 1.04e-02 NA NA NA
GO:0050839 cell adhesion molecule binding 1.10e-02 NA NA NA
GO:0061650 ubiquitin-like protein conjugating enzym... 1.22e-02 NA NA NA
GO:0003723 RNA binding 1.61e-02 NA 1.71e-06 NA
GO:0001671 ATPase activator activity 1.77e-02 NA NA NA
GO:0061135 endopeptidase regulator activity 1.77e-02 NA NA NA
GO:0004867 serine-type endopeptidase inhibitor acti... 1.77e-02 NA NA NA
GO:0098632 cell-cell adhesion mediator activity 1.80e-02 NA NA NA
GO:0016722 oxidoreductase activity, acting on metal... 2.00e-02 NA NA NA
GO:0004128 cytochrome-b5 reductase activity, acting... 2.29e-02 NA NA NA
GO:0015399 primary active transmembrane transporter... 2.50e-02 NA NA NA
GO:0046933 proton-transporting ATP synthase activit... 2.64e-02 NA NA NA
GO:0030545 signaling receptor regulator activity 2.69e-02 NA NA NA
GO:1903136 cuprous ion binding 3.23e-02 NA NA NA
GO:0055102 lipase inhibitor activity 3.23e-02 NA NA NA
GO:0042625 ATPase-coupled ion transmembrane transpo... 3.42e-02 NA NA NA
GO:0044769 ATPase activity, coupled to transmembran... 3.42e-02 NA NA NA
GO:0046961 proton-transporting ATPase activity, rot... 3.42e-02 NA NA NA
GO:0042288 MHC class I protein binding 3.64e-02 NA NA NA
GO:0030527 structural constituent of chromatin 3.72e-02 NA 2.28e-15 NA
GO:0047134 protein-disulfide reductase (NAD(P)H) ac... 3.87e-02 NA NA NA
GO:0086080 protein binding involved in heterotypic ... 3.91e-02 NA NA NA
GO:0042289 MHC class II protein binding 3.91e-02 NA NA NA
GO:0038023 signaling receptor activity 3.91e-02 NA NA NA
GO:0060089 molecular transducer activity 3.91e-02 NA NA NA
GO:0061631 ubiquitin conjugating enzyme activity 3.91e-02 NA NA NA
GO:0016655 oxidoreductase activity, acting on NAD(P... 3.91e-02 NA NA NA
GO:0016667 oxidoreductase activity, acting on a sul... 3.92e-02 NA NA NA
GO:0070851 growth factor receptor binding 4.32e-02 NA NA NA
GO:0015036 disulfide oxidoreductase activity 4.32e-02 NA NA NA
GO:0048531 beta-1,3-galactosyltransferase activity 4.33e-02 NA NA NA
GO:0031625 ubiquitin protein ligase binding 4.61e-02 NA NA NA
GO:0044389 ubiquitin-like protein ligase binding 4.61e-02 NA NA NA
GO:0098631 cell adhesion mediator activity 4.61e-02 NA NA NA
GO:0030346 protein phosphatase 2B binding 4.61e-02 NA NA NA
GO:0016615 malate dehydrogenase activity 4.64e-02 NA NA NA
GO:0030546 signaling receptor activator activity 4.65e-02 NA NA NA
GO:0032393 MHC class I receptor activity 4.75e-02 NA NA NA
GO:0048018 receptor ligand activity 4.82e-02 NA NA NA
GO:0051087 protein-folding chaperone binding 4.92e-02 NA NA NA
GO:0001618 virus receptor activity 4.92e-02 NA NA NA
GO:0140272 exogenous protein binding 4.92e-02 NA NA NA
GO:0005524 ATP binding NA 3.45e-18 NA NA
GO:0030554 adenyl nucleotide binding NA 3.45e-18 NA NA
GO:0032559 adenyl ribonucleotide binding NA 3.45e-18 NA NA
GO:0043167 ion binding NA 6.93e-11 NA NA
GO:0003677 DNA binding NA 6.93e-11 9.38e-03 NA
GO:0140993 histone modifying activity NA 1.77e-10 NA NA
GO:0004386 helicase activity NA 1.17e-09 NA NA
GO:0030695 GTPase regulator activity NA 2.20e-09 NA NA
GO:0060589 nucleoside-triphosphatase regulator acti... NA 2.20e-09 NA NA
GO:0036094 small molecule binding NA 2.20e-09 NA NA
GO:0016887 ATP hydrolysis activity NA 3.91e-09 NA NA
GO:0140097 catalytic activity, acting on DNA NA 4.69e-09 NA NA
GO:0016772 transferase activity, transferring phosp... NA 8.40e-09 NA NA
GO:0016773 phosphotransferase activity, alcohol gro... NA 9.60e-09 NA NA
GO:0140657 ATP-dependent activity NA 9.91e-09 NA NA
GO:0016301 kinase activity NA 1.07e-08 NA NA
GO:0043168 anion binding NA 1.21e-08 NA NA
GO:1901363 heterocyclic compound binding NA 1.21e-08 NA NA
GO:0032553 ribonucleotide binding NA 2.39e-08 NA NA
GO:0035639 purine ribonucleoside triphosphate bindi... NA 2.74e-08 NA NA
GO:0005096 GTPase activator activity NA 2.74e-08 NA NA
GO:0017076 purine nucleotide binding NA 3.35e-08 NA NA
GO:0032555 purine ribonucleotide binding NA 4.46e-08 NA NA
GO:0106310 protein serine kinase activity NA 8.68e-08 NA NA
GO:0000166 nucleotide binding NA 1.35e-07 NA NA
GO:1901265 nucleoside phosphate binding NA 1.35e-07 NA NA
GO:0004672 protein kinase activity NA 1.72e-07 NA NA
GO:0008094 ATP-dependent activity, acting on DNA NA 3.00e-07 NA NA
GO:0140640 catalytic activity, acting on a nucleic ... NA 3.70e-07 NA NA
GO:0004674 protein serine/threonine kinase activity NA 3.87e-07 NA NA
GO:0097159 organic cyclic compound binding NA 4.73e-06 4.24e-05 NA
GO:0003682 chromatin binding NA 4.73e-06 1.71e-06 NA
GO:0097367 carbohydrate derivative binding NA 6.25e-06 NA NA
GO:0046872 metal ion binding NA 8.65e-06 NA 2.31e-02
GO:0042393 histone binding NA 9.15e-06 NA NA
GO:0005085 guanyl-nucleotide exchange factor activi... NA 1.08e-05 NA NA
GO:0044024 histone H2AS1 kinase activity NA 2.16e-05 NA NA
GO:0140995 histone H2A kinase activity NA 2.16e-05 NA NA
GO:0035173 histone kinase activity NA 2.46e-05 NA NA
GO:0140030 modification-dependent protein binding NA 2.74e-05 NA NA
GO:0043169 cation binding NA 2.91e-05 NA 2.03e-02
GO:0017116 single-stranded DNA helicase activity NA 4.25e-05 NA NA
GO:0003678 DNA helicase activity NA 6.99e-05 NA NA
GO:0042054 histone methyltransferase activity NA 1.34e-04 NA NA
GO:0016741 transferase activity, transferring one-c... NA 1.80e-04 NA NA
GO:0016740 transferase activity NA 2.74e-04 NA NA
GO:0043565 sequence-specific DNA binding NA 3.24e-04 NA NA
GO:0008168 methyltransferase activity NA 4.16e-04 NA NA
GO:0003690 double-stranded DNA binding NA 5.82e-04 NA NA
GO:0140033 acetylation-dependent protein binding NA 5.82e-04 NA NA
GO:0140938 histone H3 methyltransferase activity NA 7.06e-04 NA NA
GO:0003689 DNA clamp loader activity NA 1.05e-03 NA NA
GO:0070577 lysine-acetylated histone binding NA 1.17e-03 NA NA
GO:0046976 histone H3K27 methyltransferase activity NA 1.36e-03 NA NA
GO:0008170 N-methyltransferase activity NA 1.89e-03 NA NA
GO:0140110 transcription regulator activity NA 2.07e-03 NA NA
GO:0008276 protein methyltransferase activity NA 2.17e-03 NA NA
GO:0004445 inositol-polyphosphate 5-phosphatase act... NA 2.43e-03 NA NA
GO:0008757 S-adenosylmethionine-dependent methyltra... NA 2.77e-03 NA NA
GO:1990837 sequence-specific double-stranded DNA bi... NA 2.99e-03 NA NA
GO:0016279 protein-lysine N-methyltransferase activ... NA 3.04e-03 NA NA
GO:0140999 histone H3K4 trimethyltransferase activi... NA 3.73e-03 NA NA
GO:0008381 mechanosensitive monoatomic ion channel ... NA 4.77e-03 NA NA
GO:0051020 GTPase binding NA 5.18e-03 NA NA
GO:0043138 3'-5' DNA helicase activity NA 5.42e-03 NA NA
GO:0031267 small GTPase binding NA 5.47e-03 NA NA
GO:0140034 methylation-dependent protein binding NA 6.55e-03 NA NA
GO:0035091 phosphatidylinositol binding NA 6.78e-03 NA NA
GO:0016278 lysine N-methyltransferase activity NA 8.79e-03 NA NA
GO:0035064 methylated histone binding NA 8.79e-03 NA NA
GO:0004683 calcium/calmodulin-dependent protein kin... NA 1.08e-02 NA NA
GO:0140947 histone H3K9me2 methyltransferase activi... NA 1.11e-02 NA NA
GO:0099094 ligand-gated monoatomic cation channel a... NA 1.11e-02 NA NA
GO:0046030 inositol trisphosphate phosphatase activ... NA 1.44e-02 NA NA
GO:0003676 nucleic acid binding NA 1.45e-02 1.71e-06 NA
GO:0000976 transcription cis-regulatory region bind... NA 1.56e-02 NA NA
GO:0001067 transcription regulatory region nucleic ... NA 1.58e-02 NA NA
GO:0008186 ATP-dependent activity, acting on RNA NA 1.60e-02 NA NA
GO:0022836 gated channel activity NA 1.69e-02 NA NA
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphata... NA 1.74e-02 NA NA
GO:0005272 sodium channel activity NA 1.84e-02 NA NA
GO:0009374 biotin binding NA 2.00e-02 NA NA
GO:0003724 RNA helicase activity NA 2.00e-02 NA NA
GO:0003712 transcription coregulator activity NA 2.00e-02 NA NA
GO:0003995 acyl-CoA dehydrogenase activity NA 2.38e-02 NA NA
GO:0052890 oxidoreductase activity, acting on the C... NA 2.38e-02 NA NA
GO:0015276 ligand-gated monoatomic ion channel acti... NA 2.70e-02 NA NA
GO:0022834 ligand-gated channel activity NA 2.84e-02 NA NA
GO:0140658 ATP-dependent chromatin remodeler activi... NA 2.99e-02 NA NA
GO:0016706 2-oxoglutarate-dependent dioxygenase act... NA 3.28e-02 NA NA
GO:0003824 catalytic activity NA 3.52e-02 NA NA
GO:0051011 microtubule minus-end binding NA 3.52e-02 NA NA
GO:0032135 DNA insertion or deletion binding NA 3.52e-02 NA NA
GO:0009008 DNA-methyltransferase activity NA 3.59e-02 NA NA
GO:0043139 5'-3' DNA helicase activity NA 4.13e-02 NA NA
GO:0016627 oxidoreductase activity, acting on the C... NA 4.19e-02 NA 2.31e-02
GO:0005003 ephrin receptor activity NA 4.39e-02 NA NA
GO:0000146 microfilament motor activity NA 4.46e-02 NA NA
GO:0051539 4 iron, 4 sulfur cluster binding NA 4.46e-02 NA NA
GO:0071889 14-3-3 protein binding NA 4.46e-02 NA NA
GO:0015280 ligand-gated sodium channel activity NA 4.46e-02 NA NA
GO:0004016 adenylate cyclase activity NA 4.51e-02 NA NA
GO:0031418 L-ascorbic acid binding NA 4.75e-02 NA NA
GO:0008289 lipid binding NA 4.89e-02 NA NA
GO:0046982 protein heterodimerization activity NA NA 2.14e-04 NA
GO:0008009 chemokine activity NA NA 1.43e-03 NA
GO:0008017 microtubule binding NA NA 3.16e-03 NA
GO:0031492 nucleosomal DNA binding NA NA 3.16e-03 NA
GO:0017111 ribonucleoside triphosphate phosphatase ... NA NA 3.16e-03 NA
GO:0005515 protein binding NA NA 9.11e-03 NA
GO:0016817 hydrolase activity, acting on acid anhyd... NA NA 1.07e-02 NA
GO:0016818 hydrolase activity, acting on acid anhyd... NA NA 1.07e-02 NA
GO:0016462 pyrophosphatase activity NA NA 1.19e-02 NA
GO:0003697 single-stranded DNA binding NA NA 2.31e-02 NA
GO:0015631 tubulin binding NA NA 4.37e-02 NA
GO:0008301 DNA binding, bending NA NA 4.61e-02 NA

Functional enrichments of HCPC clusters using all genes

This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0005096 GTPase activator activity 3.42e-02 NA NA NA
GO:0016772 transferase activity, transferring phosp... NA 3.19e-04 NA NA
GO:0036094 small molecule binding NA 1.52e-03 NA NA
GO:0030554 adenyl nucleotide binding NA 1.52e-03 NA NA
GO:0043167 ion binding NA 1.52e-03 NA NA
GO:0043169 cation binding NA 1.72e-03 NA NA
GO:0016301 kinase activity NA 1.72e-03 NA NA
GO:0046872 metal ion binding NA 2.53e-03 NA NA
GO:0005524 ATP binding NA 6.01e-03 NA NA
GO:0032559 adenyl ribonucleotide binding NA 6.01e-03 NA NA
GO:0016773 phosphotransferase activity, alcohol gro... NA 8.64e-03 NA NA
GO:0140947 histone H3K9me2 methyltransferase activi... NA 1.27e-02 NA NA
GO:0016627 oxidoreductase activity, acting on the C... NA 3.19e-02 NA NA
GO:0005543 phospholipid binding NA 3.19e-02 NA NA
GO:0003735 structural constituent of ribosome NA NA 4.00e-15 4.61e-13
GO:0030527 structural constituent of chromatin NA NA 1.96e-10 2.82e-10
GO:0005198 structural molecule activity NA NA 2.47e-08 1.61e-09
GO:0003924 GTPase activity NA NA 1.60e-07 1.03e-03
GO:0003723 RNA binding NA NA 4.93e-07 3.29e-06
GO:0003823 antigen binding NA NA 7.50e-05 1.62e-02
GO:0003925 G protein activity NA NA 7.50e-05 3.97e-03
GO:0023026 MHC class II protein complex binding NA NA 1.38e-04 2.89e-03
GO:0019001 guanyl nucleotide binding NA NA 1.38e-04 3.58e-03
GO:0032561 guanyl ribonucleotide binding NA NA 1.38e-04 3.58e-03
GO:0042605 peptide antigen binding NA NA 2.21e-04 3.97e-03
GO:0005525 GTP binding NA NA 2.21e-04 4.20e-03
GO:0019843 rRNA binding NA NA 3.89e-04 3.32e-03
GO:0046982 protein heterodimerization activity NA NA 4.55e-04 2.02e-05
GO:0023023 MHC protein complex binding NA NA 7.93e-04 3.30e-03
GO:0042287 MHC protein binding NA NA 1.02e-03 1.14e-02
GO:0019003 GDP binding NA NA 1.34e-03 9.12e-03
GO:0048027 mRNA 5'-UTR binding NA NA 1.41e-03 4.20e-03
GO:0005126 cytokine receptor binding NA NA 1.41e-03 NA
GO:0032395 MHC class II receptor activity NA NA 1.43e-03 2.78e-02
GO:0005515 protein binding NA NA 4.21e-03 9.12e-03
GO:0140678 molecular function inhibitor activity NA NA 4.34e-03 NA
GO:0045296 cadherin binding NA NA 5.36e-03 2.47e-02
GO:0050839 cell adhesion molecule binding NA NA 8.86e-03 NA
GO:0003743 translation initiation factor activity NA NA 8.86e-03 2.96e-02
GO:0061134 peptidase regulator activity NA NA 9.17e-03 4.30e-02
GO:0004576 oligosaccharyl transferase activity NA NA 9.17e-03 NA
GO:0004579 dolichyl-diphosphooligosaccharide-protei... NA NA 9.17e-03 NA
GO:0140375 immune receptor activity NA NA 1.05e-02 NA
GO:0004857 enzyme inhibitor activity NA NA 1.16e-02 NA
GO:0098632 cell-cell adhesion mediator activity NA NA 1.43e-02 NA
GO:0008009 chemokine activity NA NA 1.74e-02 4.30e-02
GO:0090079 translation regulator activity, nucleic ... NA NA 1.79e-02 NA
GO:0045182 translation regulator activity NA NA 1.99e-02 NA
GO:0042379 chemokine receptor binding NA NA 2.25e-02 NA
GO:0042277 peptide binding NA NA 2.55e-02 NA
GO:0031386 protein tag activity NA NA 2.59e-02 NA
GO:0141047 molecular tag activity NA NA 2.59e-02 NA
GO:0010854 adenylate cyclase regulator activity NA NA 2.59e-02 NA
GO:0046977 TAP binding NA NA 2.59e-02 NA
GO:0051920 peroxiredoxin activity NA NA 2.67e-02 NA
GO:0008135 translation factor activity, RNA binding NA NA 2.71e-02 NA
GO:0086080 protein binding involved in heterotypic ... NA NA 3.14e-02 NA
GO:0004791 thioredoxin-disulfide reductase (NADPH) ... NA NA 3.25e-02 NA
GO:0046983 protein dimerization activity NA NA 3.25e-02 NA
GO:0016668 oxidoreductase activity, acting on a sul... NA NA 3.25e-02 NA
GO:0016209 antioxidant activity NA NA 3.69e-02 NA
GO:0008375 acetylglucosaminyltransferase activity NA NA 3.72e-02 NA
GO:0043024 ribosomal small subunit binding NA NA 3.99e-02 NA
GO:0016504 peptidase activator activity NA NA 4.10e-02 NA
GO:0005102 signaling receptor binding NA NA 4.85e-02 NA
GO:0005125 cytokine activity NA NA NA 1.62e-02

Functional enrichments of PCs using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to PCs
GO.ID Term positive.PC.1 negative.PC.1 positive.PC.2 negative.PC.2
GO:0038023 signaling receptor activity 2.74e-03 NA NA NA
GO:0060089 molecular transducer activity 2.74e-03 NA NA NA
GO:0004888 transmembrane signaling receptor activit... 2.74e-03 NA NA NA
GO:0140096 catalytic activity, acting on a protein NA NA 4.63e-02 NA

Functional enrichments of HCPC clusters using only DEGs


This table shows the enrichment FDR of Gene ontology terms in gene contibution to HCPC clusters
GO.ID Term Cluster 1 Cluster 2 Cluster 3 Cluster 4
GO:0038023 signaling receptor activity NA 1.42e-02 NA 4.38e-03
GO:0060089 molecular transducer activity NA 1.42e-02 NA 4.38e-03
GO:0140096 catalytic activity, acting on a protein NA 2.02e-02 NA 3.26e-02
GO:0004888 transmembrane signaling receptor activit... NA 2.76e-02 NA 1.33e-02

Values of options passed to the Functional Hunter main function

First column contains the option names; second column contains the given values for each option. Note that large data objects (e.g. expression results, organism table and custom annotation files) are not shown.
final_main_params
model_organism Human
annot_table NULL
input_gene_id ENSEMBL
custom NULL
enrich_dbs c("Reactome", "KEGG", "BP", "CC", "MF")
kegg_data_file /Users/marmtnez/Desktop/Master_Bioinfo/TFM/installed_software/ExpHunterSuite/inst/scripts/../../inst/kegg_data_files/hsa_KEGG.rds
enrich_methods ORA
annotation_source orgdb
pthreshold 0.1
qthreshold 0.2
cores 1
task_size 10
output_files /Users/marmtnez/Desktop/Master_Bioinfo/TFM/Results/functional/opg_vs_gtdup_fe
fc_colname mean_logFCs
universe NULL
clean_parentals FALSE
simplify FALSE
top_categories 50
sim_thr NULL
summary_common_name ancestor
clusters_flag TRUE